Neuropsychiatric disturbances in atypical parkinsonian disorders

Daniele Belvisi,1 Isabella Berardelli,2 Antonio Suppa,1,3 Andrea Fabbrini,3 Massimo Pasquini,3 Maurizio Pompili,2 Giovanni Fabbrini1,3 1IRCCS Neuromed, Pozzilli, Italy; 2Department of Neurosciences, Mental Health and Sensory Organs, Suicide Prevention Center, Sant’Andrea Hospital, Sapienz...

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Autores principales:	Belvisi D, Berardelli I, Suppa A, Fabbrini A, Pasquini M, Pompili M, Fabbrini G
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	progressive supranuclear palsy multiple system atrophy corticobasal degeneration apathy depression disinhibition anxiety agitation obsessive compulsive disorders hallucination delusions tau alpha-synuclein Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/cd7eaac54f4741f4a9129fd22f4ea368
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spelling	oai:doaj.org-article:cd7eaac54f4741f4a9129fd22f4ea3682021-12-02T11:19:46ZNeuropsychiatric disturbances in atypical parkinsonian disorders1178-2021https://doaj.org/article/cd7eaac54f4741f4a9129fd22f4ea3682018-10-01T00:00:00Zhttps://www.dovepress.com/neuropsychiatric-disturbances-in-atypical-parkinsonian-disorders-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Daniele Belvisi,1 Isabella Berardelli,2 Antonio Suppa,1,3 Andrea Fabbrini,3 Massimo Pasquini,3 Maurizio Pompili,2 Giovanni Fabbrini1,3 1IRCCS Neuromed, Pozzilli, Italy; 2Department of Neurosciences, Mental Health and Sensory Organs, Suicide Prevention Center, Sant’Andrea Hospital, Sapienza University of Rome, Rome, Italy; 3Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy Abstract: Multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD) are the most common atypical parkinsonisms. These disorders are characterized by varying combinations of autonomic, cerebellar and pyramidal system, and cognitive dysfunctions. In this paper, we reviewed the evidence available on the presence and type of neuropsychiatric disturbances in MSA, PSP, and CBD. A MedLine, Excerpta Medica, PsycLit, PsycInfo, and Index Medicus search was performed to identify all articles published on this topic between 1965 and 2018. Neuropsychiatric disturbances including depression, anxiety, agitation, and behavioral abnormalities have been frequently described in these disorders, with depression as the most frequent disturbance. MSA patients show a higher frequency of depressive disorders when compared to healthy controls. An increased frequency of anxiety disorders has also been reported in some patients, and no studies have investigated apathy. PSP patients may have depression, apathy, disinhibition, and to a lesser extent, anxiety and agitation. In CBD, neuropsychiatric disorders are similar to those present in PSP. Hallucinations and delusions are rarely reported in these disorders. Neuropsychiatric symptoms in MSA, PSP, and CBD do not appear to be related to the severity of motor dysfunction and are one of the main factors that determine a low quality of life. The results suggest that neuropsychiatric disturbances should always be assessed in patients with atypical parkinsonisms. Keywords: atypical parkinsonisms, multiple system atrophy, progressive supranuclear palsy, corticobasal degeneration, neuropsychiatric disturbances, depressionBelvisi DBerardelli ISuppa AFabbrini APasquini MPompili MFabbrini GDove Medical Pressarticleprogressive supranuclear palsymultiple system atrophycorticobasal degenerationapathy depressiondisinhibitionanxietyagitationobsessive compulsive disordershallucinationdelusionstaualpha-synucleinNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 2643-2656 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	progressive supranuclear palsy multiple system atrophy corticobasal degeneration apathy depression disinhibition anxiety agitation obsessive compulsive disorders hallucination delusions tau alpha-synuclein Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	progressive supranuclear palsy multiple system atrophy corticobasal degeneration apathy depression disinhibition anxiety agitation obsessive compulsive disorders hallucination delusions tau alpha-synuclein Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Belvisi D Berardelli I Suppa A Fabbrini A Pasquini M Pompili M Fabbrini G Neuropsychiatric disturbances in atypical parkinsonian disorders
description	Daniele Belvisi,1 Isabella Berardelli,2 Antonio Suppa,1,3 Andrea Fabbrini,3 Massimo Pasquini,3 Maurizio Pompili,2 Giovanni Fabbrini1,3 1IRCCS Neuromed, Pozzilli, Italy; 2Department of Neurosciences, Mental Health and Sensory Organs, Suicide Prevention Center, Sant’Andrea Hospital, Sapienza University of Rome, Rome, Italy; 3Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy Abstract: Multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD) are the most common atypical parkinsonisms. These disorders are characterized by varying combinations of autonomic, cerebellar and pyramidal system, and cognitive dysfunctions. In this paper, we reviewed the evidence available on the presence and type of neuropsychiatric disturbances in MSA, PSP, and CBD. A MedLine, Excerpta Medica, PsycLit, PsycInfo, and Index Medicus search was performed to identify all articles published on this topic between 1965 and 2018. Neuropsychiatric disturbances including depression, anxiety, agitation, and behavioral abnormalities have been frequently described in these disorders, with depression as the most frequent disturbance. MSA patients show a higher frequency of depressive disorders when compared to healthy controls. An increased frequency of anxiety disorders has also been reported in some patients, and no studies have investigated apathy. PSP patients may have depression, apathy, disinhibition, and to a lesser extent, anxiety and agitation. In CBD, neuropsychiatric disorders are similar to those present in PSP. Hallucinations and delusions are rarely reported in these disorders. Neuropsychiatric symptoms in MSA, PSP, and CBD do not appear to be related to the severity of motor dysfunction and are one of the main factors that determine a low quality of life. The results suggest that neuropsychiatric disturbances should always be assessed in patients with atypical parkinsonisms. Keywords: atypical parkinsonisms, multiple system atrophy, progressive supranuclear palsy, corticobasal degeneration, neuropsychiatric disturbances, depression
format	article
author	Belvisi D Berardelli I Suppa A Fabbrini A Pasquini M Pompili M Fabbrini G
author_facet	Belvisi D Berardelli I Suppa A Fabbrini A Pasquini M Pompili M Fabbrini G
author_sort	Belvisi D
title	Neuropsychiatric disturbances in atypical parkinsonian disorders
title_short	Neuropsychiatric disturbances in atypical parkinsonian disorders
title_full	Neuropsychiatric disturbances in atypical parkinsonian disorders
title_fullStr	Neuropsychiatric disturbances in atypical parkinsonian disorders
title_full_unstemmed	Neuropsychiatric disturbances in atypical parkinsonian disorders
title_sort	neuropsychiatric disturbances in atypical parkinsonian disorders
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/cd7eaac54f4741f4a9129fd22f4ea368
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Neuropsychiatric disturbances in atypical parkinsonian disorders

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