Discovering of Genomic Variations Associated to Growth Traits by GWAS in Braunvieh Cattle

A genome-wide association study (GWAS) was performed to elucidate genetic architecture of growth traits in Braunvieh cattle. Methods: The study included 300 genotyped animals by the GeneSeek<sup>®</sup> Genomic Profiler Bovine LDv.4 panel; after quality control, 22,734 SNP and 276 animal...

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Autores principales:	José Luis Zepeda-Batista, Rafael Núñez-Domínguez, Rodolfo Ramírez-Valverde, Francisco Joel Jahuey-Martínez, Jessica Beatriz Herrera-Ojeda, Gaspar Manuel Parra-Bracamonte
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	association candidate gene growth quantitative trait loci single nucleotide polymorphism Genetics QH426-470
Acceso en línea:	https://doaj.org/article/cd82850ddda74bdc9ce320dae08f3a6f
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spelling	oai:doaj.org-article:cd82850ddda74bdc9ce320dae08f3a6f2021-11-25T17:40:29ZDiscovering of Genomic Variations Associated to Growth Traits by GWAS in Braunvieh Cattle10.3390/genes121116662073-4425https://doaj.org/article/cd82850ddda74bdc9ce320dae08f3a6f2021-10-01T00:00:00Zhttps://www.mdpi.com/2073-4425/12/11/1666https://doaj.org/toc/2073-4425A genome-wide association study (GWAS) was performed to elucidate genetic architecture of growth traits in Braunvieh cattle. Methods: The study included 300 genotyped animals by the GeneSeek<sup>®</sup> Genomic Profiler Bovine LDv.4 panel; after quality control, 22,734 SNP and 276 animals were maintained in the analysis. The examined phenotypic data considered birth (BW), weaning (WW), and yearling weights. The association analysis was performed using the principal components method via the egscore function of the GenABEL version 1.8-0 package in the R environment. The marker rs133262280 located in BTA 22 was associated with BW, and two SNPs were associated with WW, rs43668789 (BTA 11) and rs136155567 (BTA 27). New QTL associated with these liveweight traits and four positional and functional candidate genes potentially involved in variations of the analyzed traits were identified. The most important genes in these genomic regions were <i>MCM2</i> (minichromosome maintenance complex component 2), <i>TPRA1</i> (transmembrane protein adipocyte associated 1), <i>GALM</i> (<i>galactose mutarotase</i>), and <i>NRG1</i> (neuregulin 1), related to embryonic cleavage, bone and tissue growth, cell adhesion, and organic development. This study is the first to present a GWAS conducted in Braunvieh cattle in Mexico providing evidence for genetic architecture of assessed growth traits. Further specific analysis of found associated genes and regions will clarify its contribution to the genetic basis of growth-related traits.José Luis Zepeda-BatistaRafael Núñez-DomínguezRodolfo Ramírez-ValverdeFrancisco Joel Jahuey-MartínezJessica Beatriz Herrera-OjedaGaspar Manuel Parra-BracamonteMDPI AGarticleassociationcandidate genegrowthquantitative trait locisingle nucleotide polymorphismGeneticsQH426-470ENGenes, Vol 12, Iss 1666, p 1666 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	association candidate gene growth quantitative trait loci single nucleotide polymorphism Genetics QH426-470
spellingShingle	association candidate gene growth quantitative trait loci single nucleotide polymorphism Genetics QH426-470 José Luis Zepeda-Batista Rafael Núñez-Domínguez Rodolfo Ramírez-Valverde Francisco Joel Jahuey-Martínez Jessica Beatriz Herrera-Ojeda Gaspar Manuel Parra-Bracamonte Discovering of Genomic Variations Associated to Growth Traits by GWAS in Braunvieh Cattle
description	A genome-wide association study (GWAS) was performed to elucidate genetic architecture of growth traits in Braunvieh cattle. Methods: The study included 300 genotyped animals by the GeneSeek<sup>®</sup> Genomic Profiler Bovine LDv.4 panel; after quality control, 22,734 SNP and 276 animals were maintained in the analysis. The examined phenotypic data considered birth (BW), weaning (WW), and yearling weights. The association analysis was performed using the principal components method via the egscore function of the GenABEL version 1.8-0 package in the R environment. The marker rs133262280 located in BTA 22 was associated with BW, and two SNPs were associated with WW, rs43668789 (BTA 11) and rs136155567 (BTA 27). New QTL associated with these liveweight traits and four positional and functional candidate genes potentially involved in variations of the analyzed traits were identified. The most important genes in these genomic regions were <i>MCM2</i> (minichromosome maintenance complex component 2), <i>TPRA1</i> (transmembrane protein adipocyte associated 1), <i>GALM</i> (<i>galactose mutarotase</i>), and <i>NRG1</i> (neuregulin 1), related to embryonic cleavage, bone and tissue growth, cell adhesion, and organic development. This study is the first to present a GWAS conducted in Braunvieh cattle in Mexico providing evidence for genetic architecture of assessed growth traits. Further specific analysis of found associated genes and regions will clarify its contribution to the genetic basis of growth-related traits.
format	article
author	José Luis Zepeda-Batista Rafael Núñez-Domínguez Rodolfo Ramírez-Valverde Francisco Joel Jahuey-Martínez Jessica Beatriz Herrera-Ojeda Gaspar Manuel Parra-Bracamonte
author_facet	José Luis Zepeda-Batista Rafael Núñez-Domínguez Rodolfo Ramírez-Valverde Francisco Joel Jahuey-Martínez Jessica Beatriz Herrera-Ojeda Gaspar Manuel Parra-Bracamonte
author_sort	José Luis Zepeda-Batista
title	Discovering of Genomic Variations Associated to Growth Traits by GWAS in Braunvieh Cattle
title_short	Discovering of Genomic Variations Associated to Growth Traits by GWAS in Braunvieh Cattle
title_full	Discovering of Genomic Variations Associated to Growth Traits by GWAS in Braunvieh Cattle
title_fullStr	Discovering of Genomic Variations Associated to Growth Traits by GWAS in Braunvieh Cattle
title_full_unstemmed	Discovering of Genomic Variations Associated to Growth Traits by GWAS in Braunvieh Cattle
title_sort	discovering of genomic variations associated to growth traits by gwas in braunvieh cattle
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/cd82850ddda74bdc9ce320dae08f3a6f
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Discovering of Genomic Variations Associated to Growth Traits by GWAS in Braunvieh Cattle

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