Childhood tuberculosis in household contacts of newly diagnosed TB patients.

<h4>Introduction</h4>Childhood tuberculosis (TB), although estimated to account for a major proportion of the global TB disease burden, has a lower public health priority. Reliable research and surveillance data on childhood TB is limited in most regions of the world. This study was cond...

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Autores principales:	Srichand Batra, Afsheen Ayaz, Ali Murtaza, Shakil Ahmad, Rumina Hasan, Ruth Pfau
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cd8297c5330b40d2a80df4713869bd53
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spelling	oai:doaj.org-article:cd8297c5330b40d2a80df4713869bd532021-11-18T07:10:19ZChildhood tuberculosis in household contacts of newly diagnosed TB patients.1932-620310.1371/journal.pone.0040880https://doaj.org/article/cd8297c5330b40d2a80df4713869bd532012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22859957/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Introduction</h4>Childhood tuberculosis (TB), although estimated to account for a major proportion of the global TB disease burden, has a lower public health priority. Reliable research and surveillance data on childhood TB is limited in most regions of the world. This study was conducted to assess the burden of childhood TB among the household contacts of new TB patients in Karachi, Pakistan.<h4>Methods</h4>A retrospective analysis of children (<15 years) who were household contacts of new adult TB patients presenting to Marie Adelaide Leprosy Center (MALC) clinics in Karachi during the period of 2008 to 2010 was conducted.<h4>Results</h4>Of the household children contacts (n = 6613) screened, 317 were suspected and 121(1.8%) diagnosed with TB. These included 89 (73.6%) with pulmonary and 32 (26.4%) with extra-pulmonary disease. Smear positivity rate in pulmonary cases was 32.6%. Mean age of children diagnosed with TB was 11.7 (± 2.8) years. Within the child-contacts screened, disease was found to be significantly higher among females (2.3%) in comparison to males (1.2%) (p-value <0.01). The commonest relationship of source cases to diagnosed children was the mother (n = 51, 42.1%). The source case was a female for 66.1% (n = 76) of the children.<h4>Conclusion</h4>A smear positivity rate of 32.6% amongst pulmonary cases suggests their potential to spread disease and emphasizes a need to review the contribution of children in transmission of TB within communities. Greater vulnerability of the female child and considerable role of mother in disease transmission highlights a need to increase focus on females in TB control programs in Pakistan.Srichand BatraAfsheen AyazAli MurtazaShakil AhmadRumina HasanRuth PfauPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 7, p e40880 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Srichand Batra Afsheen Ayaz Ali Murtaza Shakil Ahmad Rumina Hasan Ruth Pfau Childhood tuberculosis in household contacts of newly diagnosed TB patients.
description	<h4>Introduction</h4>Childhood tuberculosis (TB), although estimated to account for a major proportion of the global TB disease burden, has a lower public health priority. Reliable research and surveillance data on childhood TB is limited in most regions of the world. This study was conducted to assess the burden of childhood TB among the household contacts of new TB patients in Karachi, Pakistan.<h4>Methods</h4>A retrospective analysis of children (<15 years) who were household contacts of new adult TB patients presenting to Marie Adelaide Leprosy Center (MALC) clinics in Karachi during the period of 2008 to 2010 was conducted.<h4>Results</h4>Of the household children contacts (n = 6613) screened, 317 were suspected and 121(1.8%) diagnosed with TB. These included 89 (73.6%) with pulmonary and 32 (26.4%) with extra-pulmonary disease. Smear positivity rate in pulmonary cases was 32.6%. Mean age of children diagnosed with TB was 11.7 (± 2.8) years. Within the child-contacts screened, disease was found to be significantly higher among females (2.3%) in comparison to males (1.2%) (p-value <0.01). The commonest relationship of source cases to diagnosed children was the mother (n = 51, 42.1%). The source case was a female for 66.1% (n = 76) of the children.<h4>Conclusion</h4>A smear positivity rate of 32.6% amongst pulmonary cases suggests their potential to spread disease and emphasizes a need to review the contribution of children in transmission of TB within communities. Greater vulnerability of the female child and considerable role of mother in disease transmission highlights a need to increase focus on females in TB control programs in Pakistan.
format	article
author	Srichand Batra Afsheen Ayaz Ali Murtaza Shakil Ahmad Rumina Hasan Ruth Pfau
author_facet	Srichand Batra Afsheen Ayaz Ali Murtaza Shakil Ahmad Rumina Hasan Ruth Pfau
author_sort	Srichand Batra
title	Childhood tuberculosis in household contacts of newly diagnosed TB patients.
title_short	Childhood tuberculosis in household contacts of newly diagnosed TB patients.
title_full	Childhood tuberculosis in household contacts of newly diagnosed TB patients.
title_fullStr	Childhood tuberculosis in household contacts of newly diagnosed TB patients.
title_full_unstemmed	Childhood tuberculosis in household contacts of newly diagnosed TB patients.
title_sort	childhood tuberculosis in household contacts of newly diagnosed tb patients.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/cd8297c5330b40d2a80df4713869bd53
work_keys_str_mv	AT srichandbatra childhoodtuberculosisinhouseholdcontactsofnewlydiagnosedtbpatients AT afsheenayaz childhoodtuberculosisinhouseholdcontactsofnewlydiagnosedtbpatients AT alimurtaza childhoodtuberculosisinhouseholdcontactsofnewlydiagnosedtbpatients AT shakilahmad childhoodtuberculosisinhouseholdcontactsofnewlydiagnosedtbpatients AT ruminahasan childhoodtuberculosisinhouseholdcontactsofnewlydiagnosedtbpatients AT ruthpfau childhoodtuberculosisinhouseholdcontactsofnewlydiagnosedtbpatients
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Childhood tuberculosis in household contacts of newly diagnosed TB patients.

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