DJ-1 suppresses ferroptosis through preserving the activity of S-adenosyl homocysteine hydrolase

DJ-1 protects cells from oxidative stress-induced cell death; however its role in ferroptosis is unclear. Here, the authors show that DJ-1 suppresses ferroptosis through the transsulfuration pathway to compensate for the depletion of intracellular cysteine when cystine import is inhibited.

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Auteurs principaux:	Ji Cao, Xiaobing Chen, Li Jiang, Bin Lu, Meng Yuan, Difeng Zhu, Hong Zhu, Qiaojun He, Bo Yang, Meidan Ying
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2020
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/cd84a2a1c9554ac791e7edd5b93d0ee2
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id	oai:doaj.org-article:cd84a2a1c9554ac791e7edd5b93d0ee2
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spelling	oai:doaj.org-article:cd84a2a1c9554ac791e7edd5b93d0ee22021-12-02T14:42:46ZDJ-1 suppresses ferroptosis through preserving the activity of S-adenosyl homocysteine hydrolase10.1038/s41467-020-15109-y2041-1723https://doaj.org/article/cd84a2a1c9554ac791e7edd5b93d0ee22020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15109-yhttps://doaj.org/toc/2041-1723DJ-1 protects cells from oxidative stress-induced cell death; however its role in ferroptosis is unclear. Here, the authors show that DJ-1 suppresses ferroptosis through the transsulfuration pathway to compensate for the depletion of intracellular cysteine when cystine import is inhibited.Ji CaoXiaobing ChenLi JiangBin LuMeng YuanDifeng ZhuHong ZhuQiaojun HeBo YangMeidan YingNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ji Cao Xiaobing Chen Li Jiang Bin Lu Meng Yuan Difeng Zhu Hong Zhu Qiaojun He Bo Yang Meidan Ying DJ-1 suppresses ferroptosis through preserving the activity of S-adenosyl homocysteine hydrolase
description	DJ-1 protects cells from oxidative stress-induced cell death; however its role in ferroptosis is unclear. Here, the authors show that DJ-1 suppresses ferroptosis through the transsulfuration pathway to compensate for the depletion of intracellular cysteine when cystine import is inhibited.
format	article
author	Ji Cao Xiaobing Chen Li Jiang Bin Lu Meng Yuan Difeng Zhu Hong Zhu Qiaojun He Bo Yang Meidan Ying
author_facet	Ji Cao Xiaobing Chen Li Jiang Bin Lu Meng Yuan Difeng Zhu Hong Zhu Qiaojun He Bo Yang Meidan Ying
author_sort	Ji Cao
title	DJ-1 suppresses ferroptosis through preserving the activity of S-adenosyl homocysteine hydrolase
title_short	DJ-1 suppresses ferroptosis through preserving the activity of S-adenosyl homocysteine hydrolase
title_full	DJ-1 suppresses ferroptosis through preserving the activity of S-adenosyl homocysteine hydrolase
title_fullStr	DJ-1 suppresses ferroptosis through preserving the activity of S-adenosyl homocysteine hydrolase
title_full_unstemmed	DJ-1 suppresses ferroptosis through preserving the activity of S-adenosyl homocysteine hydrolase
title_sort	dj-1 suppresses ferroptosis through preserving the activity of s-adenosyl homocysteine hydrolase
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/cd84a2a1c9554ac791e7edd5b93d0ee2
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DJ-1 suppresses ferroptosis through preserving the activity of S-adenosyl homocysteine hydrolase

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