Dysfunctional BTN3A together with deregulated immune checkpoints and type I/II IFN dictate defective interplay between pDCs and γδ T cells in melanoma patients, which impacts clinical outcomes

Dysfunctional BTN3A together with deregulated immune checkpoints and type I/II IFN dictate defective interplay between pDCs and γδ T cells in melanoma patients, which impacts clinical outcomes

Abstract Objectives pDCs and γδ T cells emerge as potent immune players participating in the pathophysiology of cancers, yet still remaining enigmatic while harbouring a promising potential for clinical translations. Despite strategic and closed missions, crosstalk between pDCs and γδ T cells has no...

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Autores principales: Pauline Girard, Eleonora Sosa Cuevas, Benedicte Ponsard, Stephane Mouret, Hugo Gil, Edwige Col, Florence De Fraipont, Nathalie Sturm, Julie Charles, Olivier Manches, Laurence Chaperot, Caroline Aspord
Formato: article
Lenguaje:EN
Publicado: Wiley 2021
Materias:
BTN3A
immune subversion
melanoma
pDCs
γδ T cells
Immunologic diseases. Allergy
RC581-607
Acceso en línea:https://doaj.org/article/cd84e9bba19f4244a20d06c6ed117e9c
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