Germ granule dysfunction is a hallmark and mirror of Piwi mutant sterility

Piwi deficiency results in sterility and is associated with transposon expression and genomic instability. Here the authors show that sterility of C. elegans Piwi prg-1 mutant is not associated with transposon-induced DNA damage but is associated with and is phenocopied by dysfunction of germ granul...

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Autores principales:	Maya Spichal, Bree Heestand, Katherine Kretovich Billmyre, Stephen Frenk, Craig C. Mello, Shawn Ahmed
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cd88eb970a0243c88484b5de38732fcb
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spelling	oai:doaj.org-article:cd88eb970a0243c88484b5de38732fcb2021-12-02T13:14:59ZGerm granule dysfunction is a hallmark and mirror of Piwi mutant sterility10.1038/s41467-021-21635-02041-1723https://doaj.org/article/cd88eb970a0243c88484b5de38732fcb2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21635-0https://doaj.org/toc/2041-1723Piwi deficiency results in sterility and is associated with transposon expression and genomic instability. Here the authors show that sterility of C. elegans Piwi prg-1 mutant is not associated with transposon-induced DNA damage but is associated with and is phenocopied by dysfunction of germ granules.Maya SpichalBree HeestandKatherine Kretovich BillmyreStephen FrenkCraig C. MelloShawn AhmedNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Maya Spichal Bree Heestand Katherine Kretovich Billmyre Stephen Frenk Craig C. Mello Shawn Ahmed Germ granule dysfunction is a hallmark and mirror of Piwi mutant sterility
description	Piwi deficiency results in sterility and is associated with transposon expression and genomic instability. Here the authors show that sterility of C. elegans Piwi prg-1 mutant is not associated with transposon-induced DNA damage but is associated with and is phenocopied by dysfunction of germ granules.
format	article
author	Maya Spichal Bree Heestand Katherine Kretovich Billmyre Stephen Frenk Craig C. Mello Shawn Ahmed
author_facet	Maya Spichal Bree Heestand Katherine Kretovich Billmyre Stephen Frenk Craig C. Mello Shawn Ahmed
author_sort	Maya Spichal
title	Germ granule dysfunction is a hallmark and mirror of Piwi mutant sterility
title_short	Germ granule dysfunction is a hallmark and mirror of Piwi mutant sterility
title_full	Germ granule dysfunction is a hallmark and mirror of Piwi mutant sterility
title_fullStr	Germ granule dysfunction is a hallmark and mirror of Piwi mutant sterility
title_full_unstemmed	Germ granule dysfunction is a hallmark and mirror of Piwi mutant sterility
title_sort	germ granule dysfunction is a hallmark and mirror of piwi mutant sterility
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/cd88eb970a0243c88484b5de38732fcb
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Germ granule dysfunction is a hallmark and mirror of Piwi mutant sterility

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