TiO2 nanotube platforms for smart drug delivery: a review

Qun Wang,1,2,* Jian-Ying Huang,1,* Hua-Qiong Li,3 Zhong Chen,4 Allan Zi-Jian Zhao,3 Yi Wang,3 Ke-Qin Zhang,1 Hong-Tao Sun,2 Salem S Al-Deyab,5 Yue-Kun Lai1 1National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou, 2College of Chemistr...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Wang Q, Huang JY, Li HQ, Chen Z, Zhao AZJ, Wang Y, Zhang KQ, Sun HT, Al-Deyab SS, Lai YK
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	TiO2 nanotubes anodization drug delivery orthopedic implant Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/cd8a9d0ad6044e7c906eba8dd555ef4b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:cd8a9d0ad6044e7c906eba8dd555ef4b
record_format	dspace
spelling	oai:doaj.org-article:cd8a9d0ad6044e7c906eba8dd555ef4b2021-12-02T08:07:46ZTiO2 nanotube platforms for smart drug delivery: a review1178-2013https://doaj.org/article/cd8a9d0ad6044e7c906eba8dd555ef4b2016-09-01T00:00:00Zhttps://www.dovepress.com/tio2-nanotube-platforms-for-smart-drug-delivery-a-review-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Qun Wang,1,2,* Jian-Ying Huang,1,* Hua-Qiong Li,3 Zhong Chen,4 Allan Zi-Jian Zhao,3 Yi Wang,3 Ke-Qin Zhang,1 Hong-Tao Sun,2 Salem S Al-Deyab,5 Yue-Kun Lai1 1National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou, 2College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, People’s Republic of China; 3Wenzhou Institute of Biomaterials and Engineering, Chinese Academy of Sciences, Wenzhou, People’s Republic of China; 4School of Materials Science and Engineering, Nanyang Technological University, Singapore, Singapore; 5Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia *These authors contributed equally to this work Abstract: Titania nanotube (TNT) arrays are recognized as promising materials for localized drug delivery implants because of their excellent properties and facile preparation process. This review highlights the concept of localized drug delivery systems based on TNTs, considering their outstanding biocompatibility in a series of ex vivo and in vivo studies. Considering the safety of TNT implants in the host body, studies of the biocompatibility present significant importance for the clinical application of TNT implants. Toward smart TNT platforms for sustainable drug delivery, several advanced approaches were presented in this review, including controlled release triggered by temperature, light, radiofrequency magnetism, and ultrasonic stimulation. Moreover, TNT implants used in medical therapy have been demonstrated by various examples including dentistry, orthopedic implants, cardiovascular stents, and so on. Finally, a future perspective of TNTs for clinical applications is provided. Keywords: TiO2 nanotubes, anodization, drug delivery, orthopedic implantWang QHuang JYLi HQChen ZZhao AZJWang YZhang KQSun HTAl-Deyab SSLai YKDove Medical PressarticleTiO2 nanotubesanodizationdrug deliveryorthopedic implantMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 11, Pp 4819-4834 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	TiO2 nanotubes anodization drug delivery orthopedic implant Medicine (General) R5-920
spellingShingle	TiO2 nanotubes anodization drug delivery orthopedic implant Medicine (General) R5-920 Wang Q Huang JY Li HQ Chen Z Zhao AZJ Wang Y Zhang KQ Sun HT Al-Deyab SS Lai YK TiO2 nanotube platforms for smart drug delivery: a review
description	Qun Wang,1,2,* Jian-Ying Huang,1,* Hua-Qiong Li,3 Zhong Chen,4 Allan Zi-Jian Zhao,3 Yi Wang,3 Ke-Qin Zhang,1 Hong-Tao Sun,2 Salem S Al-Deyab,5 Yue-Kun Lai1 1National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou, 2College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, People’s Republic of China; 3Wenzhou Institute of Biomaterials and Engineering, Chinese Academy of Sciences, Wenzhou, People’s Republic of China; 4School of Materials Science and Engineering, Nanyang Technological University, Singapore, Singapore; 5Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia *These authors contributed equally to this work Abstract: Titania nanotube (TNT) arrays are recognized as promising materials for localized drug delivery implants because of their excellent properties and facile preparation process. This review highlights the concept of localized drug delivery systems based on TNTs, considering their outstanding biocompatibility in a series of ex vivo and in vivo studies. Considering the safety of TNT implants in the host body, studies of the biocompatibility present significant importance for the clinical application of TNT implants. Toward smart TNT platforms for sustainable drug delivery, several advanced approaches were presented in this review, including controlled release triggered by temperature, light, radiofrequency magnetism, and ultrasonic stimulation. Moreover, TNT implants used in medical therapy have been demonstrated by various examples including dentistry, orthopedic implants, cardiovascular stents, and so on. Finally, a future perspective of TNTs for clinical applications is provided. Keywords: TiO2 nanotubes, anodization, drug delivery, orthopedic implant
format	article
author	Wang Q Huang JY Li HQ Chen Z Zhao AZJ Wang Y Zhang KQ Sun HT Al-Deyab SS Lai YK
author_facet	Wang Q Huang JY Li HQ Chen Z Zhao AZJ Wang Y Zhang KQ Sun HT Al-Deyab SS Lai YK
author_sort	Wang Q
title	TiO2 nanotube platforms for smart drug delivery: a review
title_short	TiO2 nanotube platforms for smart drug delivery: a review
title_full	TiO2 nanotube platforms for smart drug delivery: a review
title_fullStr	TiO2 nanotube platforms for smart drug delivery: a review
title_full_unstemmed	TiO2 nanotube platforms for smart drug delivery: a review
title_sort	tio2 nanotube platforms for smart drug delivery: a review
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/cd8a9d0ad6044e7c906eba8dd555ef4b
work_keys_str_mv	AT wangq tio2nanotubeplatformsforsmartdrugdeliveryareview AT huangjy tio2nanotubeplatformsforsmartdrugdeliveryareview AT lihq tio2nanotubeplatformsforsmartdrugdeliveryareview AT chenz tio2nanotubeplatformsforsmartdrugdeliveryareview AT zhaoazj tio2nanotubeplatformsforsmartdrugdeliveryareview AT wangy tio2nanotubeplatformsforsmartdrugdeliveryareview AT zhangkq tio2nanotubeplatformsforsmartdrugdeliveryareview AT sunht tio2nanotubeplatformsforsmartdrugdeliveryareview AT aldeyabss tio2nanotubeplatformsforsmartdrugdeliveryareview AT laiyk tio2nanotubeplatformsforsmartdrugdeliveryareview
_version_	1718398626855649280

TiO2 nanotube platforms for smart drug delivery: a review

Ejemplares similares