Maternal–Fetal Outcomes in Women with Endometriosis and Shared Pathogenic Mechanisms

The connection between endometriosis and pregnancy outcomes is trending among the research topics. Until recently, endometriosis and its painful symptomatology were considered to be alleviated by pregnancy. However, these beliefs have shifted, as emerging literature has demonstrated the role of this...

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Autores principales:	Francesca Frincu, Andreea Carp-Veliscu, Aida Petca, Dumitru-Cristinel Badiu, Elvira Bratila, Monica Cirstoiu, Claudia Mehedintu
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	endometriosis obstetric complications preeclampsia hemorrhages miscarriage Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/cd8d744c10384fb4befd677afc53900a
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spelling	oai:doaj.org-article:cd8d744c10384fb4befd677afc53900a2021-11-25T18:19:00ZMaternal–Fetal Outcomes in Women with Endometriosis and Shared Pathogenic Mechanisms10.3390/medicina571112581648-91441010-660Xhttps://doaj.org/article/cd8d744c10384fb4befd677afc53900a2021-11-01T00:00:00Zhttps://www.mdpi.com/1648-9144/57/11/1258https://doaj.org/toc/1010-660Xhttps://doaj.org/toc/1648-9144The connection between endometriosis and pregnancy outcomes is trending among the research topics. Until recently, endometriosis and its painful symptomatology were considered to be alleviated by pregnancy. However, these beliefs have shifted, as emerging literature has demonstrated the role of this condition in affecting pregnancy evolution. The underlying pathogenesis of endometriosis is still poorly understood, all the more when pregnancy complications are involved. Debatable opinions on endometriosis associated with obstetric complications exist because of the potential bias resulting from the heterogeneity of preceding evidence. This review aims to evaluate the connection between endometriosis and adverse pregnancy outcomes and their shared pathogenic mechanisms. We searched PubMed and EMBASE and focused on the studies that include placenta praevia, premature rupture of membranes, spontaneous preterm birth, gestational hypertension, preeclampsia, obstetric hemorrhages (ante- and postpartum bleeding, abruptio placentae), miscarriage, stillbirth, neonatal death, gestational diabetes mellitus, gestational cholestasis, small for gestational age, and their association with endometriosis. Not only the risks of emergence were highlighted, but also the pathogenic connections. Epigenetic alterations of some genes were found to be mirrored both in endometriosis and obstetric complications. This review issues a warning for providing increased attention to pregnant women with endometriosis and newborns as higher risks of preeclampsia, placental issues, and preterm deliveries are associated.Francesca FrincuAndreea Carp-VeliscuAida PetcaDumitru-Cristinel BadiuElvira BratilaMonica CirstoiuClaudia MehedintuMDPI AGarticleendometriosisobstetriccomplicationspreeclampsiahemorrhagesmiscarriageMedicine (General)R5-920ENMedicina, Vol 57, Iss 1258, p 1258 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	endometriosis obstetric complications preeclampsia hemorrhages miscarriage Medicine (General) R5-920
spellingShingle	endometriosis obstetric complications preeclampsia hemorrhages miscarriage Medicine (General) R5-920 Francesca Frincu Andreea Carp-Veliscu Aida Petca Dumitru-Cristinel Badiu Elvira Bratila Monica Cirstoiu Claudia Mehedintu Maternal–Fetal Outcomes in Women with Endometriosis and Shared Pathogenic Mechanisms
description	The connection between endometriosis and pregnancy outcomes is trending among the research topics. Until recently, endometriosis and its painful symptomatology were considered to be alleviated by pregnancy. However, these beliefs have shifted, as emerging literature has demonstrated the role of this condition in affecting pregnancy evolution. The underlying pathogenesis of endometriosis is still poorly understood, all the more when pregnancy complications are involved. Debatable opinions on endometriosis associated with obstetric complications exist because of the potential bias resulting from the heterogeneity of preceding evidence. This review aims to evaluate the connection between endometriosis and adverse pregnancy outcomes and their shared pathogenic mechanisms. We searched PubMed and EMBASE and focused on the studies that include placenta praevia, premature rupture of membranes, spontaneous preterm birth, gestational hypertension, preeclampsia, obstetric hemorrhages (ante- and postpartum bleeding, abruptio placentae), miscarriage, stillbirth, neonatal death, gestational diabetes mellitus, gestational cholestasis, small for gestational age, and their association with endometriosis. Not only the risks of emergence were highlighted, but also the pathogenic connections. Epigenetic alterations of some genes were found to be mirrored both in endometriosis and obstetric complications. This review issues a warning for providing increased attention to pregnant women with endometriosis and newborns as higher risks of preeclampsia, placental issues, and preterm deliveries are associated.
format	article
author	Francesca Frincu Andreea Carp-Veliscu Aida Petca Dumitru-Cristinel Badiu Elvira Bratila Monica Cirstoiu Claudia Mehedintu
author_facet	Francesca Frincu Andreea Carp-Veliscu Aida Petca Dumitru-Cristinel Badiu Elvira Bratila Monica Cirstoiu Claudia Mehedintu
author_sort	Francesca Frincu
title	Maternal–Fetal Outcomes in Women with Endometriosis and Shared Pathogenic Mechanisms
title_short	Maternal–Fetal Outcomes in Women with Endometriosis and Shared Pathogenic Mechanisms
title_full	Maternal–Fetal Outcomes in Women with Endometriosis and Shared Pathogenic Mechanisms
title_fullStr	Maternal–Fetal Outcomes in Women with Endometriosis and Shared Pathogenic Mechanisms
title_full_unstemmed	Maternal–Fetal Outcomes in Women with Endometriosis and Shared Pathogenic Mechanisms
title_sort	maternal–fetal outcomes in women with endometriosis and shared pathogenic mechanisms
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/cd8d744c10384fb4befd677afc53900a
work_keys_str_mv	AT francescafrincu maternalfetaloutcomesinwomenwithendometriosisandsharedpathogenicmechanisms AT andreeacarpveliscu maternalfetaloutcomesinwomenwithendometriosisandsharedpathogenicmechanisms AT aidapetca maternalfetaloutcomesinwomenwithendometriosisandsharedpathogenicmechanisms AT dumitrucristinelbadiu maternalfetaloutcomesinwomenwithendometriosisandsharedpathogenicmechanisms AT elvirabratila maternalfetaloutcomesinwomenwithendometriosisandsharedpathogenicmechanisms AT monicacirstoiu maternalfetaloutcomesinwomenwithendometriosisandsharedpathogenicmechanisms AT claudiamehedintu maternalfetaloutcomesinwomenwithendometriosisandsharedpathogenicmechanisms
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Maternal–Fetal Outcomes in Women with Endometriosis and Shared Pathogenic Mechanisms

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