Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin

The molecular circuitry that drives dendrite formation during osteocytogenesis remains poorly understood. Here the authors show that deletion of Sp7, a gene linked to rare and common skeletal disease, in mature osteoblasts and osteocytes causes severe defects in osteocyte dendrites.

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Autores principales:	Jialiang S. Wang, Tushar Kamath, Courtney M. Mazur, Fatemeh Mirzamohammadi, Daniel Rotter, Hironori Hojo, Christian D. Castro, Nicha Tokavanich, Rushi Patel, Nicolas Govea, Tetsuya Enishi, Yunshu Wu, Janaina da Silva Martins, Michael Bruce, Daniel J. Brooks, Mary L. Bouxsein, Danielle Tokarz, Charles P. Lin, Abdul Abdul, Evan Z. Macosko, Melissa Fiscaletti, Craig F. Munns, Pearl Ryder, Maria Kost-Alimova, Patrick Byrne, Beth Cimini, Makoto Fujiwara, Henry M. Kronenberg, Marc N. Wein
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cd91057df8104b6bb42af0b42b4a9105
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spelling	oai:doaj.org-article:cd91057df8104b6bb42af0b42b4a91052021-11-08T11:08:24ZControl of osteocyte dendrite formation by Sp7 and its target gene osteocrin10.1038/s41467-021-26571-72041-1723https://doaj.org/article/cd91057df8104b6bb42af0b42b4a91052021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26571-7https://doaj.org/toc/2041-1723The molecular circuitry that drives dendrite formation during osteocytogenesis remains poorly understood. Here the authors show that deletion of Sp7, a gene linked to rare and common skeletal disease, in mature osteoblasts and osteocytes causes severe defects in osteocyte dendrites.Jialiang S. WangTushar KamathCourtney M. MazurFatemeh MirzamohammadiDaniel RotterHironori HojoChristian D. CastroNicha TokavanichRushi PatelNicolas GoveaTetsuya EnishiYunshu WuJanaina da Silva MartinsMichael BruceDaniel J. BrooksMary L. BouxseinDanielle TokarzCharles P. LinAbdul AbdulEvan Z. MacoskoMelissa FiscalettiCraig F. MunnsPearl RyderMaria Kost-AlimovaPatrick ByrneBeth CiminiMakoto FujiwaraHenry M. KronenbergMarc N. WeinNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jialiang S. Wang Tushar Kamath Courtney M. Mazur Fatemeh Mirzamohammadi Daniel Rotter Hironori Hojo Christian D. Castro Nicha Tokavanich Rushi Patel Nicolas Govea Tetsuya Enishi Yunshu Wu Janaina da Silva Martins Michael Bruce Daniel J. Brooks Mary L. Bouxsein Danielle Tokarz Charles P. Lin Abdul Abdul Evan Z. Macosko Melissa Fiscaletti Craig F. Munns Pearl Ryder Maria Kost-Alimova Patrick Byrne Beth Cimini Makoto Fujiwara Henry M. Kronenberg Marc N. Wein Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin
description	The molecular circuitry that drives dendrite formation during osteocytogenesis remains poorly understood. Here the authors show that deletion of Sp7, a gene linked to rare and common skeletal disease, in mature osteoblasts and osteocytes causes severe defects in osteocyte dendrites.
format	article
author	Jialiang S. Wang Tushar Kamath Courtney M. Mazur Fatemeh Mirzamohammadi Daniel Rotter Hironori Hojo Christian D. Castro Nicha Tokavanich Rushi Patel Nicolas Govea Tetsuya Enishi Yunshu Wu Janaina da Silva Martins Michael Bruce Daniel J. Brooks Mary L. Bouxsein Danielle Tokarz Charles P. Lin Abdul Abdul Evan Z. Macosko Melissa Fiscaletti Craig F. Munns Pearl Ryder Maria Kost-Alimova Patrick Byrne Beth Cimini Makoto Fujiwara Henry M. Kronenberg Marc N. Wein
author_facet	Jialiang S. Wang Tushar Kamath Courtney M. Mazur Fatemeh Mirzamohammadi Daniel Rotter Hironori Hojo Christian D. Castro Nicha Tokavanich Rushi Patel Nicolas Govea Tetsuya Enishi Yunshu Wu Janaina da Silva Martins Michael Bruce Daniel J. Brooks Mary L. Bouxsein Danielle Tokarz Charles P. Lin Abdul Abdul Evan Z. Macosko Melissa Fiscaletti Craig F. Munns Pearl Ryder Maria Kost-Alimova Patrick Byrne Beth Cimini Makoto Fujiwara Henry M. Kronenberg Marc N. Wein
author_sort	Jialiang S. Wang
title	Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin
title_short	Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin
title_full	Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin
title_fullStr	Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin
title_full_unstemmed	Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin
title_sort	control of osteocyte dendrite formation by sp7 and its target gene osteocrin
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/cd91057df8104b6bb42af0b42b4a9105
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Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin

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