Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin

Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin

The molecular circuitry that drives dendrite formation during osteocytogenesis remains poorly understood. Here the authors show that deletion of Sp7, a gene linked to rare and common skeletal disease, in mature osteoblasts and osteocytes causes severe defects in osteocyte dendrites.

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Bibliographic Details
Main Authors: Jialiang S. Wang, Tushar Kamath, Courtney M. Mazur, Fatemeh Mirzamohammadi, Daniel Rotter, Hironori Hojo, Christian D. Castro, Nicha Tokavanich, Rushi Patel, Nicolas Govea, Tetsuya Enishi, Yunshu Wu, Janaina da Silva Martins, Michael Bruce, Daniel J. Brooks, Mary L. Bouxsein, Danielle Tokarz, Charles P. Lin, Abdul Abdul, Evan Z. Macosko, Melissa Fiscaletti, Craig F. Munns, Pearl Ryder, Maria Kost-Alimova, Patrick Byrne, Beth Cimini, Makoto Fujiwara, Henry M. Kronenberg, Marc N. Wein
Format: article
Language:EN
Published: Nature Portfolio 2021
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Science
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Online Access:https://doaj.org/article/cd91057df8104b6bb42af0b42b4a9105
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https://doaj.org/article/cd91057df8104b6bb42af0b42b4a9105

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