Metabolic and Bactericidal Effects of Targeted Suppression of NadD and NadE Enzymes in Mycobacteria

ABSTRACT Mycobacterium tuberculosis remains a major cause of death due to the lack of treatment accessibility, HIV coinfection, and drug resistance. Development of new drugs targeting previously unexplored pathways is essential to shorten treatment time and eliminate persistent M. tuberculosis. A pr...

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Main Authors: Irina A. Rodionova, Brian M. Schuster, Kristine M. Guinn, Leonardo Sorci, David A. Scott, Xiaoqing Li, Indu Kheterpal, Carolyn Shoen, Michael Cynamon, Christopher Locher, Eric J. Rubin, Andrei L. Osterman
Format: article
Language:EN
Published: American Society for Microbiology 2014
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Online Access:https://doaj.org/article/cd928a37779048cf85d827e12f5c4f8d
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