A combination strategy targeting enhancer plasticity exerts synergistic lethality against BETi-resistant leukemia cells

Epigenetic changes can drive drug resistance in cancer. Here, the authors show that in BET inhibitor resistant leukaemia cells, genome-wide enhancer remodelling drives therapeutic resistance and targeting enhancer plasticity may overcome this resistance.

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Autores principales:	Lei Guo, Jia Li, Hongxiang Zeng, Anna G. Guzman, Tingting Li, Minjung Lee, Yubin Zhou, Margaret A. Goodell, Clifford Stephan, Peter J. A. Davies, Mark A Dawson, Deqiang Sun, Yun Huang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cd93c24dbe33431eb092362dd139a9cb
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spelling	oai:doaj.org-article:cd93c24dbe33431eb092362dd139a9cb2021-12-02T17:33:00ZA combination strategy targeting enhancer plasticity exerts synergistic lethality against BETi-resistant leukemia cells10.1038/s41467-020-14604-62041-1723https://doaj.org/article/cd93c24dbe33431eb092362dd139a9cb2020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14604-6https://doaj.org/toc/2041-1723Epigenetic changes can drive drug resistance in cancer. Here, the authors show that in BET inhibitor resistant leukaemia cells, genome-wide enhancer remodelling drives therapeutic resistance and targeting enhancer plasticity may overcome this resistance.Lei GuoJia LiHongxiang ZengAnna G. GuzmanTingting LiMinjung LeeYubin ZhouMargaret A. GoodellClifford StephanPeter J. A. DaviesMark A DawsonDeqiang SunYun HuangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lei Guo Jia Li Hongxiang Zeng Anna G. Guzman Tingting Li Minjung Lee Yubin Zhou Margaret A. Goodell Clifford Stephan Peter J. A. Davies Mark A Dawson Deqiang Sun Yun Huang A combination strategy targeting enhancer plasticity exerts synergistic lethality against BETi-resistant leukemia cells
description	Epigenetic changes can drive drug resistance in cancer. Here, the authors show that in BET inhibitor resistant leukaemia cells, genome-wide enhancer remodelling drives therapeutic resistance and targeting enhancer plasticity may overcome this resistance.
format	article
author	Lei Guo Jia Li Hongxiang Zeng Anna G. Guzman Tingting Li Minjung Lee Yubin Zhou Margaret A. Goodell Clifford Stephan Peter J. A. Davies Mark A Dawson Deqiang Sun Yun Huang
author_facet	Lei Guo Jia Li Hongxiang Zeng Anna G. Guzman Tingting Li Minjung Lee Yubin Zhou Margaret A. Goodell Clifford Stephan Peter J. A. Davies Mark A Dawson Deqiang Sun Yun Huang
author_sort	Lei Guo
title	A combination strategy targeting enhancer plasticity exerts synergistic lethality against BETi-resistant leukemia cells
title_short	A combination strategy targeting enhancer plasticity exerts synergistic lethality against BETi-resistant leukemia cells
title_full	A combination strategy targeting enhancer plasticity exerts synergistic lethality against BETi-resistant leukemia cells
title_fullStr	A combination strategy targeting enhancer plasticity exerts synergistic lethality against BETi-resistant leukemia cells
title_full_unstemmed	A combination strategy targeting enhancer plasticity exerts synergistic lethality against BETi-resistant leukemia cells
title_sort	combination strategy targeting enhancer plasticity exerts synergistic lethality against beti-resistant leukemia cells
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/cd93c24dbe33431eb092362dd139a9cb
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A combination strategy targeting enhancer plasticity exerts synergistic lethality against BETi-resistant leukemia cells

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