A combination strategy targeting enhancer plasticity exerts synergistic lethality against BETi-resistant leukemia cells

A combination strategy targeting enhancer plasticity exerts synergistic lethality against BETi-resistant leukemia cells

Epigenetic changes can drive drug resistance in cancer. Here, the authors show that in BET inhibitor resistant leukaemia cells, genome-wide enhancer remodelling drives therapeutic resistance and targeting enhancer plasticity may overcome this resistance.

Saved in:
Bibliographic Details
Main Authors: Lei Guo, Jia Li, Hongxiang Zeng, Anna G. Guzman, Tingting Li, Minjung Lee, Yubin Zhou, Margaret A. Goodell, Clifford Stephan, Peter J. A. Davies, Mark A Dawson, Deqiang Sun, Yun Huang
Format: article
Language:EN
Published: Nature Portfolio 2020
Subjects:
Science
Q
Online Access:https://doaj.org/article/cd93c24dbe33431eb092362dd139a9cb
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doaj.org/article/cd93c24dbe33431eb092362dd139a9cb

Similar Items