A combination strategy targeting enhancer plasticity exerts synergistic lethality against BETi-resistant leukemia cells

A combination strategy targeting enhancer plasticity exerts synergistic lethality against BETi-resistant leukemia cells

Epigenetic changes can drive drug resistance in cancer. Here, the authors show that in BET inhibitor resistant leukaemia cells, genome-wide enhancer remodelling drives therapeutic resistance and targeting enhancer plasticity may overcome this resistance.

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Detalles Bibliográficos
Autores principales: Lei Guo, Jia Li, Hongxiang Zeng, Anna G. Guzman, Tingting Li, Minjung Lee, Yubin Zhou, Margaret A. Goodell, Clifford Stephan, Peter J. A. Davies, Mark A Dawson, Deqiang Sun, Yun Huang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Science
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Acceso en línea:https://doaj.org/article/cd93c24dbe33431eb092362dd139a9cb
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