A numerical investigation of changes in lens shape during accommodation

Abstract The purpose of this study was to investigate how the mechanical properties and geometry of the lens influence the changes in lens shape during accommodation. To do so, ex vivo stretching tests of the isolated lens were simulated via finite element analysis. In these tests, the lens is stret...

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Autores principales:	I. Cabeza-Gil, J. Grasa, B. Calvo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cd98f8301c5b4569ae767bfb311ec2f7
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spelling	oai:doaj.org-article:cd98f8301c5b4569ae767bfb311ec2f72021-12-02T15:38:23ZA numerical investigation of changes in lens shape during accommodation10.1038/s41598-021-89145-z2045-2322https://doaj.org/article/cd98f8301c5b4569ae767bfb311ec2f72021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89145-zhttps://doaj.org/toc/2045-2322Abstract The purpose of this study was to investigate how the mechanical properties and geometry of the lens influence the changes in lens shape during accommodation. To do so, ex vivo stretching tests of the isolated lens were simulated via finite element analysis. In these tests, the lens is stretched from the accommodated state to the non-accommodated state. Several key characteristics of the lens were studied: the stiffness gradient of the lens material, the distribution of the capsule thickness, the mechanical properties of the capsule and the material comprising the lens, nucleus and cortex, and the influence of two different age-related lens geometries (17 and 29 y/o subjects). To determine the effects on the changes in lens shape during accommodation, changes in the anterior and posterior radius, the lens and nucleus thicknesses and the equatorial lens diameter were analysed. The results suggest that multiple factors exert statistically significant influences on how the lens changes its shape, but two factors predominate over the rest: the stiffness ratio between the nucleus and cortex and the stiffness of the capsule, specifically the posterior surface.I. Cabeza-GilJ. GrasaB. CalvoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q I. Cabeza-Gil J. Grasa B. Calvo A numerical investigation of changes in lens shape during accommodation
description	Abstract The purpose of this study was to investigate how the mechanical properties and geometry of the lens influence the changes in lens shape during accommodation. To do so, ex vivo stretching tests of the isolated lens were simulated via finite element analysis. In these tests, the lens is stretched from the accommodated state to the non-accommodated state. Several key characteristics of the lens were studied: the stiffness gradient of the lens material, the distribution of the capsule thickness, the mechanical properties of the capsule and the material comprising the lens, nucleus and cortex, and the influence of two different age-related lens geometries (17 and 29 y/o subjects). To determine the effects on the changes in lens shape during accommodation, changes in the anterior and posterior radius, the lens and nucleus thicknesses and the equatorial lens diameter were analysed. The results suggest that multiple factors exert statistically significant influences on how the lens changes its shape, but two factors predominate over the rest: the stiffness ratio between the nucleus and cortex and the stiffness of the capsule, specifically the posterior surface.
format	article
author	I. Cabeza-Gil J. Grasa B. Calvo
author_facet	I. Cabeza-Gil J. Grasa B. Calvo
author_sort	I. Cabeza-Gil
title	A numerical investigation of changes in lens shape during accommodation
title_short	A numerical investigation of changes in lens shape during accommodation
title_full	A numerical investigation of changes in lens shape during accommodation
title_fullStr	A numerical investigation of changes in lens shape during accommodation
title_full_unstemmed	A numerical investigation of changes in lens shape during accommodation
title_sort	numerical investigation of changes in lens shape during accommodation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/cd98f8301c5b4569ae767bfb311ec2f7
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A numerical investigation of changes in lens shape during accommodation

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