Real-time monitoring of single ZTP riboswitches reveals a complex and kinetically controlled decision landscape
Many RNAs become functional before their synthesis completes. Here the authors employ a single-molecule vectorial folding assay mimicking RNA transcription and show that the ZTP riboswitch is kinetically controlled and activated by slower unwinding and strategic pausing.
Guardado en:
Autores principales: | Boyang Hua, Christopher P. Jones, Jaba Mitra, Peter J. Murray, Rebecca Rosenthal, Adrian R. Ferré-D’Amaré, Taekjip Ha |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2020
|
Materias: | |
Acceso en línea: | https://doaj.org/article/cd9a444440f54f6dbaa2b5c8d83e460c |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Nanomechanics and co-transcriptional folding of Spinach and Mango
por: Jaba Mitra, et al.
Publicado: (2019) -
Synthetic ligands for PreQ1 riboswitches provide structural and mechanistic insights into targeting RNA tertiary structure
por: Colleen M. Connelly, et al.
Publicado: (2019) -
Ribo-attenuators: novel elements for reliable and modular riboswitch engineering
por: Thomas Folliard, et al.
Publicado: (2017) -
SAM-VI riboswitch structure and signature for ligand discrimination
por: Aiai Sun, et al.
Publicado: (2019) -
Hierarchical mechanism of amino acid sensing by the T-box riboswitch
por: Krishna C. Suddala, et al.
Publicado: (2018)