Brain leptin reduces liver lipids by increasing hepatic triglyceride secretion and lowering lipogenesis

Brain leptin reduces liver lipids by increasing hepatic triglyceride secretion and lowering lipogenesis

Obesity is associated with leptin resistance and rising blood leptin levels while central leptin exposure may be limited. Here, the authors show that brain leptin infusion reduces hepatic lipid content in rats by increasing hepatic VLDL secretion and lowering liver de novo lipogenesis via a vagal me...

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Autores principales: Martina Theresa Hackl, Clemens Fürnsinn, Christina Maria Schuh, Martin Krssak, Fabrizia Carli, Sara Guerra, Angelika Freudenthaler, Sabina Baumgartner-Parzer, Thomas H. Helbich, Anton Luger, Maximilian Zeyda, Amalia Gastaldelli, Christoph Buettner, Thomas Scherer
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/cd9c6af3dc684233ae9e0068539f7123
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Sumario:Obesity is associated with leptin resistance and rising blood leptin levels while central leptin exposure may be limited. Here, the authors show that brain leptin infusion reduces hepatic lipid content in rats by increasing hepatic VLDL secretion and lowering liver de novo lipogenesis via a vagal mechanism.

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