Low-energy electrons transform the nimorazole molecule into a radiosensitiser

Radiosensitisers are believed to interfere with cancer cells by dissociating upon interaction with electrons. Here the authors observe instead that the dominant path for nitroimidazolic radiosensitisers involves formation of a non-dissociated radical anion, prerequisite for their accumulation in tum...

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Autores principales:	Rebecca Meißner, Jaroslav Kočišek, Linda Feketeová, Juraj Fedor, Michal Fárník, Paulo Limão-Vieira, Eugen Illenberger, Stephan Denifl
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cd9cad2156bb416a9e119dc7b675e27c
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spelling	oai:doaj.org-article:cd9cad2156bb416a9e119dc7b675e27c2021-12-02T15:35:51ZLow-energy electrons transform the nimorazole molecule into a radiosensitiser10.1038/s41467-019-10340-82041-1723https://doaj.org/article/cd9cad2156bb416a9e119dc7b675e27c2019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10340-8https://doaj.org/toc/2041-1723Radiosensitisers are believed to interfere with cancer cells by dissociating upon interaction with electrons. Here the authors observe instead that the dominant path for nitroimidazolic radiosensitisers involves formation of a non-dissociated radical anion, prerequisite for their accumulation in tumour cells.Rebecca MeißnerJaroslav KočišekLinda FeketeováJuraj FedorMichal FárníkPaulo Limão-VieiraEugen IllenbergerStephan DeniflNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-7 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rebecca Meißner Jaroslav Kočišek Linda Feketeová Juraj Fedor Michal Fárník Paulo Limão-Vieira Eugen Illenberger Stephan Denifl Low-energy electrons transform the nimorazole molecule into a radiosensitiser
description	Radiosensitisers are believed to interfere with cancer cells by dissociating upon interaction with electrons. Here the authors observe instead that the dominant path for nitroimidazolic radiosensitisers involves formation of a non-dissociated radical anion, prerequisite for their accumulation in tumour cells.
format	article
author	Rebecca Meißner Jaroslav Kočišek Linda Feketeová Juraj Fedor Michal Fárník Paulo Limão-Vieira Eugen Illenberger Stephan Denifl
author_facet	Rebecca Meißner Jaroslav Kočišek Linda Feketeová Juraj Fedor Michal Fárník Paulo Limão-Vieira Eugen Illenberger Stephan Denifl
author_sort	Rebecca Meißner
title	Low-energy electrons transform the nimorazole molecule into a radiosensitiser
title_short	Low-energy electrons transform the nimorazole molecule into a radiosensitiser
title_full	Low-energy electrons transform the nimorazole molecule into a radiosensitiser
title_fullStr	Low-energy electrons transform the nimorazole molecule into a radiosensitiser
title_full_unstemmed	Low-energy electrons transform the nimorazole molecule into a radiosensitiser
title_sort	low-energy electrons transform the nimorazole molecule into a radiosensitiser
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/cd9cad2156bb416a9e119dc7b675e27c
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Low-energy electrons transform the nimorazole molecule into a radiosensitiser

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