Prediction of severe neonatal hyperbilirubinemia using cord blood hydrogen peroxide: a prospective study.

<h4>Background</h4>We hypothesized that cord blood hydrogen peroxide (H2O2) could be utilized to predict the severity of neonatal hyperbilirubinemia.<h4>Methods</h4>We prospectively enrolled term or near-term healthy neonates. Cord blood and capillary blood at three days of a...

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Autores principales:	Hung-Chieh Chou, Chiang-Ting Chien, Po-Nien Tsao, Wu-Shiun Hsieh, Chien-Yi Chen, Mei-Hwei Chang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cd9cf83153a04ae1ae920fa009152ae5
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spelling	oai:doaj.org-article:cd9cf83153a04ae1ae920fa009152ae52021-11-18T08:36:04ZPrediction of severe neonatal hyperbilirubinemia using cord blood hydrogen peroxide: a prospective study.1932-620310.1371/journal.pone.0086797https://doaj.org/article/cd9cf83153a04ae1ae920fa009152ae52014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24466244/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>We hypothesized that cord blood hydrogen peroxide (H2O2) could be utilized to predict the severity of neonatal hyperbilirubinemia.<h4>Methods</h4>We prospectively enrolled term or near-term healthy neonates. Cord blood and capillary blood at three days of age were measured for hydrogen peroxide and bilirubin concentrations. For newborns with hyperbilirubinemia, further blood samples were obtained at five and seven days of age. Newborns were divided into severe or less severe hyperbilirubinemic groups (peak bilirubin ≥17 mg/dL or not). The sensitivity, specificity, and negative predictive values were determined.<h4>Results</h4>There were 158 neonates enrolled. The incidence of neonatal hyperbilirubinemia was 30.5% for a concentration ≥15 mg/dl. The rising patterns were similar among bilirubin concentrations and hydrogen peroxide levels during the first few days of life. There was a strong positive correlation between bilirubin concentrations and hydrogen peroxide levels after correlation analysis. The rate of severe hyperbilirubinemia was 13.3%. It revealed that a cord blood hydrogen peroxide signal level of 2500 counts/10 seconds was an appropriate cut-off for predicting severe hyperbilirubinemia. Sensitivity and the negative predictive value were 76.2% and 93.3%, respectively.<h4>Conclusions</h4>Our findings confirm that hydrogen peroxide levels and bilirubin concentrations in cord and neonatal blood are closely related. A cord blood hydrogen peroxide level above 2500 counts/10 seconds associated with a high predictive value for severe hyperbilirubinemia. This method provides information about which neonate should be closely followed after discharge from the nursery.Hung-Chieh ChouChiang-Ting ChienPo-Nien TsaoWu-Shiun HsiehChien-Yi ChenMei-Hwei ChangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 1, p e86797 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hung-Chieh Chou Chiang-Ting Chien Po-Nien Tsao Wu-Shiun Hsieh Chien-Yi Chen Mei-Hwei Chang Prediction of severe neonatal hyperbilirubinemia using cord blood hydrogen peroxide: a prospective study.
description	<h4>Background</h4>We hypothesized that cord blood hydrogen peroxide (H2O2) could be utilized to predict the severity of neonatal hyperbilirubinemia.<h4>Methods</h4>We prospectively enrolled term or near-term healthy neonates. Cord blood and capillary blood at three days of age were measured for hydrogen peroxide and bilirubin concentrations. For newborns with hyperbilirubinemia, further blood samples were obtained at five and seven days of age. Newborns were divided into severe or less severe hyperbilirubinemic groups (peak bilirubin ≥17 mg/dL or not). The sensitivity, specificity, and negative predictive values were determined.<h4>Results</h4>There were 158 neonates enrolled. The incidence of neonatal hyperbilirubinemia was 30.5% for a concentration ≥15 mg/dl. The rising patterns were similar among bilirubin concentrations and hydrogen peroxide levels during the first few days of life. There was a strong positive correlation between bilirubin concentrations and hydrogen peroxide levels after correlation analysis. The rate of severe hyperbilirubinemia was 13.3%. It revealed that a cord blood hydrogen peroxide signal level of 2500 counts/10 seconds was an appropriate cut-off for predicting severe hyperbilirubinemia. Sensitivity and the negative predictive value were 76.2% and 93.3%, respectively.<h4>Conclusions</h4>Our findings confirm that hydrogen peroxide levels and bilirubin concentrations in cord and neonatal blood are closely related. A cord blood hydrogen peroxide level above 2500 counts/10 seconds associated with a high predictive value for severe hyperbilirubinemia. This method provides information about which neonate should be closely followed after discharge from the nursery.
format	article
author	Hung-Chieh Chou Chiang-Ting Chien Po-Nien Tsao Wu-Shiun Hsieh Chien-Yi Chen Mei-Hwei Chang
author_facet	Hung-Chieh Chou Chiang-Ting Chien Po-Nien Tsao Wu-Shiun Hsieh Chien-Yi Chen Mei-Hwei Chang
author_sort	Hung-Chieh Chou
title	Prediction of severe neonatal hyperbilirubinemia using cord blood hydrogen peroxide: a prospective study.
title_short	Prediction of severe neonatal hyperbilirubinemia using cord blood hydrogen peroxide: a prospective study.
title_full	Prediction of severe neonatal hyperbilirubinemia using cord blood hydrogen peroxide: a prospective study.
title_fullStr	Prediction of severe neonatal hyperbilirubinemia using cord blood hydrogen peroxide: a prospective study.
title_full_unstemmed	Prediction of severe neonatal hyperbilirubinemia using cord blood hydrogen peroxide: a prospective study.
title_sort	prediction of severe neonatal hyperbilirubinemia using cord blood hydrogen peroxide: a prospective study.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/cd9cf83153a04ae1ae920fa009152ae5
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Prediction of severe neonatal hyperbilirubinemia using cord blood hydrogen peroxide: a prospective study.

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