Uterine glands coordinate on-time embryo implantation and impact endometrial decidualization for pregnancy success

The transcription factor FOXA2 is specifically expressed in uterine glands. Here, using two conditional FOXA2 knockout mouse models, the authors show that glandular epithelia of the endometrium are required for timely embryo implantation and subsequent endometrial decidualization during successful p...

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Autores principales: Andrew M. Kelleher, Jessica Milano-Foster, Susanta K. Behura, Thomas E. Spencer
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/cdb4aecdb05a4e399460b8626a609838
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Sumario:The transcription factor FOXA2 is specifically expressed in uterine glands. Here, using two conditional FOXA2 knockout mouse models, the authors show that glandular epithelia of the endometrium are required for timely embryo implantation and subsequent endometrial decidualization during successful pregnancy establishment.