CACNA1C polymorphisms Impact Cognitive Recovery in Patients with Bipolar Disorder in a Six-week Open-label Trial

Abstract Cognitive impairments in bipolar patients deteriorate as the disorder progresses. Little is known about whether genetic risks impact cognitive recovery during the course from depression to remission. In this six-week open-label trial, we shed light on the impacts of six single nucleotide po...

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Autores principales:	Kangguang Lin, Guiyun Xu, Lingling Shi, Weicong Lu, Lijie Guan, Huiyi Ouyang, Kun Chen, Yamei Dang, Libing Zhou, Kwok-Fai So
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cdb55be6415a45c2a3e1083d46f9e791
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spelling	oai:doaj.org-article:cdb55be6415a45c2a3e1083d46f9e7912021-12-02T11:53:01ZCACNA1C polymorphisms Impact Cognitive Recovery in Patients with Bipolar Disorder in a Six-week Open-label Trial10.1038/s41598-017-07368-52045-2322https://doaj.org/article/cdb55be6415a45c2a3e1083d46f9e7912017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07368-5https://doaj.org/toc/2045-2322Abstract Cognitive impairments in bipolar patients deteriorate as the disorder progresses. Little is known about whether genetic risks impact cognitive recovery during the course from depression to remission. In this six-week open-label trial, we shed light on the impacts of six single nucleotide polymorphisms (SNPs) in the calcium voltage-gated channel subunit alpha1 C (CACNA1C) gene on cognitive recovery in 192 bipolar patients suffering a major depressive episode (MDE). The primary outcome measures were changes in a battery of neuropsychological tests following 6-week treatment. Carriers with rs10466907 GT genotype did not significantly improve their executive function total scores on the Wisconsin Card Sorting Test after six weeks of treatment compared to the TT genotypes (β = −0.944, 95% Confidence Interval (CI) = −1.482–−0.405). Moreover, during a MDE carriers with rs58619945 GG and GA genotypes performed significantly worse than those with AA genotype on the categories completed (p = 0.013 and p = 0.001), total errors (p = 0.039 and p = 0.009), and random errors (p = 0.055 and p = 0.014, respectively). Our data suggest that the tested CACNA1C SNPs may have impacts on cognitive recovery from depression.Kangguang LinGuiyun XuLingling ShiWeicong LuLijie GuanHuiyi OuyangKun ChenYamei DangLibing ZhouKwok-Fai SoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kangguang Lin Guiyun Xu Lingling Shi Weicong Lu Lijie Guan Huiyi Ouyang Kun Chen Yamei Dang Libing Zhou Kwok-Fai So CACNA1C polymorphisms Impact Cognitive Recovery in Patients with Bipolar Disorder in a Six-week Open-label Trial
description	Abstract Cognitive impairments in bipolar patients deteriorate as the disorder progresses. Little is known about whether genetic risks impact cognitive recovery during the course from depression to remission. In this six-week open-label trial, we shed light on the impacts of six single nucleotide polymorphisms (SNPs) in the calcium voltage-gated channel subunit alpha1 C (CACNA1C) gene on cognitive recovery in 192 bipolar patients suffering a major depressive episode (MDE). The primary outcome measures were changes in a battery of neuropsychological tests following 6-week treatment. Carriers with rs10466907 GT genotype did not significantly improve their executive function total scores on the Wisconsin Card Sorting Test after six weeks of treatment compared to the TT genotypes (β = −0.944, 95% Confidence Interval (CI) = −1.482–−0.405). Moreover, during a MDE carriers with rs58619945 GG and GA genotypes performed significantly worse than those with AA genotype on the categories completed (p = 0.013 and p = 0.001), total errors (p = 0.039 and p = 0.009), and random errors (p = 0.055 and p = 0.014, respectively). Our data suggest that the tested CACNA1C SNPs may have impacts on cognitive recovery from depression.
format	article
author	Kangguang Lin Guiyun Xu Lingling Shi Weicong Lu Lijie Guan Huiyi Ouyang Kun Chen Yamei Dang Libing Zhou Kwok-Fai So
author_facet	Kangguang Lin Guiyun Xu Lingling Shi Weicong Lu Lijie Guan Huiyi Ouyang Kun Chen Yamei Dang Libing Zhou Kwok-Fai So
author_sort	Kangguang Lin
title	CACNA1C polymorphisms Impact Cognitive Recovery in Patients with Bipolar Disorder in a Six-week Open-label Trial
title_short	CACNA1C polymorphisms Impact Cognitive Recovery in Patients with Bipolar Disorder in a Six-week Open-label Trial
title_full	CACNA1C polymorphisms Impact Cognitive Recovery in Patients with Bipolar Disorder in a Six-week Open-label Trial
title_fullStr	CACNA1C polymorphisms Impact Cognitive Recovery in Patients with Bipolar Disorder in a Six-week Open-label Trial
title_full_unstemmed	CACNA1C polymorphisms Impact Cognitive Recovery in Patients with Bipolar Disorder in a Six-week Open-label Trial
title_sort	cacna1c polymorphisms impact cognitive recovery in patients with bipolar disorder in a six-week open-label trial
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/cdb55be6415a45c2a3e1083d46f9e791
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CACNA1C polymorphisms Impact Cognitive Recovery in Patients with Bipolar Disorder in a Six-week Open-label Trial

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