Association Between Base Excess and Mortality Among Patients in ICU With Acute Kidney Injury
Objective: This study aimed to explore the association between base excess (BE) and the risk of 30-day mortality among patients with acute kidney injury (AKI) in the intensive care unit (ICU).Methods: This retrospective study included patients with AKI from the Medical Information Mart for Intensive...
Guardado en:
| Autores principales: | , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Frontiers Media S.A.
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/cdb5711a3ff64a49a287094d6d3d695f |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:cdb5711a3ff64a49a287094d6d3d695f |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:cdb5711a3ff64a49a287094d6d3d695f2021-12-02T09:38:51ZAssociation Between Base Excess and Mortality Among Patients in ICU With Acute Kidney Injury2296-858X10.3389/fmed.2021.779627https://doaj.org/article/cdb5711a3ff64a49a287094d6d3d695f2021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.779627/fullhttps://doaj.org/toc/2296-858XObjective: This study aimed to explore the association between base excess (BE) and the risk of 30-day mortality among patients with acute kidney injury (AKI) in the intensive care unit (ICU).Methods: This retrospective study included patients with AKI from the Medical Information Mart for Intensive Care (MIMIC)-IV database. We used a multivariate Cox proportional-hazards model to obtain the hazard ratio (HR) for the risk of 30-day mortality among patients with AKI. Furthermore, we utilized a Cox proportional-hazard model with restricted cubic splines (RCS) to explore the potential non-linear associations.Results: Among the 14,238 ICU patients with AKI, BE showed a U-shaped relationship with risk of 30-day mortality for patients with AKI, and higher or lower BE values could increase the risk. Compared with normal base excess (−3~3 mEq/L), patients in different groups (BE ≤ −9 mEq/L, −9 mEq/L < BE ≤ −3 mEq/L, 3 mEq/L < BE ≤ 9 mEq/L, and BE > 9 mEq/L) had different HRs for mortality: 1.57 (1.40, 1.76), 1.26 (1.14, 1.39), 0.97 (0.83, 1.12), 1.53 (1.17, 2.02), respectively. The RCS analyses also showed a U-shaped curve between BE and the 30-day mortality risk.Conclusion: Our results suggest that higher and lower BE in patients with AKI would increase the risk of 30-day mortality. BE measured at administration could be a critical prognostic indicator for ICU patients with AKI and provide guidance for clinicians.Yi ChengYou ZhangBoxiang TuYingyi QinXin ChengRan QiWei GuoDongdong LiShengyong WuRonghui ZhuYanfang ZhaoYuanjun TangCheng WuFrontiers Media S.A.articlebase excessacute kidney injury30-day mortalityrestrict cubic splinesMIMIC-IVMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
base excess acute kidney injury 30-day mortality restrict cubic splines MIMIC-IV Medicine (General) R5-920 |
| spellingShingle |
base excess acute kidney injury 30-day mortality restrict cubic splines MIMIC-IV Medicine (General) R5-920 Yi Cheng You Zhang Boxiang Tu Yingyi Qin Xin Cheng Ran Qi Wei Guo Dongdong Li Shengyong Wu Ronghui Zhu Yanfang Zhao Yuanjun Tang Cheng Wu Association Between Base Excess and Mortality Among Patients in ICU With Acute Kidney Injury |
| description |
Objective: This study aimed to explore the association between base excess (BE) and the risk of 30-day mortality among patients with acute kidney injury (AKI) in the intensive care unit (ICU).Methods: This retrospective study included patients with AKI from the Medical Information Mart for Intensive Care (MIMIC)-IV database. We used a multivariate Cox proportional-hazards model to obtain the hazard ratio (HR) for the risk of 30-day mortality among patients with AKI. Furthermore, we utilized a Cox proportional-hazard model with restricted cubic splines (RCS) to explore the potential non-linear associations.Results: Among the 14,238 ICU patients with AKI, BE showed a U-shaped relationship with risk of 30-day mortality for patients with AKI, and higher or lower BE values could increase the risk. Compared with normal base excess (−3~3 mEq/L), patients in different groups (BE ≤ −9 mEq/L, −9 mEq/L < BE ≤ −3 mEq/L, 3 mEq/L < BE ≤ 9 mEq/L, and BE > 9 mEq/L) had different HRs for mortality: 1.57 (1.40, 1.76), 1.26 (1.14, 1.39), 0.97 (0.83, 1.12), 1.53 (1.17, 2.02), respectively. The RCS analyses also showed a U-shaped curve between BE and the 30-day mortality risk.Conclusion: Our results suggest that higher and lower BE in patients with AKI would increase the risk of 30-day mortality. BE measured at administration could be a critical prognostic indicator for ICU patients with AKI and provide guidance for clinicians. |
| format |
article |
| author |
Yi Cheng You Zhang Boxiang Tu Yingyi Qin Xin Cheng Ran Qi Wei Guo Dongdong Li Shengyong Wu Ronghui Zhu Yanfang Zhao Yuanjun Tang Cheng Wu |
| author_facet |
Yi Cheng You Zhang Boxiang Tu Yingyi Qin Xin Cheng Ran Qi Wei Guo Dongdong Li Shengyong Wu Ronghui Zhu Yanfang Zhao Yuanjun Tang Cheng Wu |
| author_sort |
Yi Cheng |
| title |
Association Between Base Excess and Mortality Among Patients in ICU With Acute Kidney Injury |
| title_short |
Association Between Base Excess and Mortality Among Patients in ICU With Acute Kidney Injury |
| title_full |
Association Between Base Excess and Mortality Among Patients in ICU With Acute Kidney Injury |
| title_fullStr |
Association Between Base Excess and Mortality Among Patients in ICU With Acute Kidney Injury |
| title_full_unstemmed |
Association Between Base Excess and Mortality Among Patients in ICU With Acute Kidney Injury |
| title_sort |
association between base excess and mortality among patients in icu with acute kidney injury |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/cdb5711a3ff64a49a287094d6d3d695f |
| work_keys_str_mv |
AT yicheng associationbetweenbaseexcessandmortalityamongpatientsinicuwithacutekidneyinjury AT youzhang associationbetweenbaseexcessandmortalityamongpatientsinicuwithacutekidneyinjury AT boxiangtu associationbetweenbaseexcessandmortalityamongpatientsinicuwithacutekidneyinjury AT yingyiqin associationbetweenbaseexcessandmortalityamongpatientsinicuwithacutekidneyinjury AT xincheng associationbetweenbaseexcessandmortalityamongpatientsinicuwithacutekidneyinjury AT ranqi associationbetweenbaseexcessandmortalityamongpatientsinicuwithacutekidneyinjury AT weiguo associationbetweenbaseexcessandmortalityamongpatientsinicuwithacutekidneyinjury AT dongdongli associationbetweenbaseexcessandmortalityamongpatientsinicuwithacutekidneyinjury AT shengyongwu associationbetweenbaseexcessandmortalityamongpatientsinicuwithacutekidneyinjury AT ronghuizhu associationbetweenbaseexcessandmortalityamongpatientsinicuwithacutekidneyinjury AT yanfangzhao associationbetweenbaseexcessandmortalityamongpatientsinicuwithacutekidneyinjury AT yuanjuntang associationbetweenbaseexcessandmortalityamongpatientsinicuwithacutekidneyinjury AT chengwu associationbetweenbaseexcessandmortalityamongpatientsinicuwithacutekidneyinjury |
| _version_ |
1718398090309795840 |