Internal pressure driven finite element model of a single pulmonary acinus

A computer simulated, poroelastic, hyperelastic model was developed to replicate the pressure-volume response of a single pulmonary acinus (15th branch of the respiratory tree and daughter branches) with air flow at its core. An internal pressure driven approach was taken upon a small spherical geom...

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Autores principales:	Campbell James, Siddiqui Salman, Gill Simon, Tsamis Alkiviadis
Formato:	article
Lenguaje:	EN FR
Publicado:	EDP Sciences 2021
Materias:	Engineering (General). Civil engineering (General) TA1-2040
Acceso en línea:	https://doaj.org/article/cdb677b6b7164450a6b0e6c5e782778f
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spelling	oai:doaj.org-article:cdb677b6b7164450a6b0e6c5e782778f2021-12-02T17:13:46ZInternal pressure driven finite element model of a single pulmonary acinus2261-236X10.1051/matecconf/202134903008https://doaj.org/article/cdb677b6b7164450a6b0e6c5e782778f2021-01-01T00:00:00Zhttps://www.matec-conferences.org/articles/matecconf/pdf/2021/18/matecconf_iceaf2021_03008.pdfhttps://doaj.org/toc/2261-236XA computer simulated, poroelastic, hyperelastic model was developed to replicate the pressure-volume response of a single pulmonary acinus (15th branch of the respiratory tree and daughter branches) with air flow at its core. An internal pressure driven approach was taken upon a small spherical geometry (99.2 mm3 in volume) representing this small segment of lung parenchyma. A reference porcine tracheal pressure at tidal breathing was adjusted from 1471 Pa to 998 Pa to accommodate for pressure drop, and the pressure of 998 Pa was applied to the model for parametric analysis of its pressure-volume characteristics. In targeting a proportional tidal volume change of approximately 15% while also inducing a pressure-volume hysteresis, material parameters of Young’s modulus of 4 kPa, Poisson’s ratio of 0.4, and a permeability of 5×10-5 cm3s-1cm-2 were identified as suitable. The energy loss over a single pressure-volume cycle for a pulmonary acinus was found to be 6.3×10-6 J. This model was qualitatively compared to the pressure-volume relationship of the original porcine data source, and then with experimental findings of the material parameters for lung parenchyma in medical literature, demonstrating same-order agreement.Campbell JamesSiddiqui SalmanGill SimonTsamis AlkiviadisEDP SciencesarticleEngineering (General). Civil engineering (General)TA1-2040ENFRMATEC Web of Conferences, Vol 349, p 03008 (2021)
institution	DOAJ
collection	DOAJ
language	EN FR
topic	Engineering (General). Civil engineering (General) TA1-2040
spellingShingle	Engineering (General). Civil engineering (General) TA1-2040 Campbell James Siddiqui Salman Gill Simon Tsamis Alkiviadis Internal pressure driven finite element model of a single pulmonary acinus
description	A computer simulated, poroelastic, hyperelastic model was developed to replicate the pressure-volume response of a single pulmonary acinus (15th branch of the respiratory tree and daughter branches) with air flow at its core. An internal pressure driven approach was taken upon a small spherical geometry (99.2 mm3 in volume) representing this small segment of lung parenchyma. A reference porcine tracheal pressure at tidal breathing was adjusted from 1471 Pa to 998 Pa to accommodate for pressure drop, and the pressure of 998 Pa was applied to the model for parametric analysis of its pressure-volume characteristics. In targeting a proportional tidal volume change of approximately 15% while also inducing a pressure-volume hysteresis, material parameters of Young’s modulus of 4 kPa, Poisson’s ratio of 0.4, and a permeability of 5×10-5 cm3s-1cm-2 were identified as suitable. The energy loss over a single pressure-volume cycle for a pulmonary acinus was found to be 6.3×10-6 J. This model was qualitatively compared to the pressure-volume relationship of the original porcine data source, and then with experimental findings of the material parameters for lung parenchyma in medical literature, demonstrating same-order agreement.
format	article
author	Campbell James Siddiqui Salman Gill Simon Tsamis Alkiviadis
author_facet	Campbell James Siddiqui Salman Gill Simon Tsamis Alkiviadis
author_sort	Campbell James
title	Internal pressure driven finite element model of a single pulmonary acinus
title_short	Internal pressure driven finite element model of a single pulmonary acinus
title_full	Internal pressure driven finite element model of a single pulmonary acinus
title_fullStr	Internal pressure driven finite element model of a single pulmonary acinus
title_full_unstemmed	Internal pressure driven finite element model of a single pulmonary acinus
title_sort	internal pressure driven finite element model of a single pulmonary acinus
publisher	EDP Sciences
publishDate	2021
url	https://doaj.org/article/cdb677b6b7164450a6b0e6c5e782778f
work_keys_str_mv	AT campbelljames internalpressuredrivenfiniteelementmodelofasinglepulmonaryacinus AT siddiquisalman internalpressuredrivenfiniteelementmodelofasinglepulmonaryacinus AT gillsimon internalpressuredrivenfiniteelementmodelofasinglepulmonaryacinus AT tsamisalkiviadis internalpressuredrivenfiniteelementmodelofasinglepulmonaryacinus
_version_	1718381346594750464

Internal pressure driven finite element model of a single pulmonary acinus

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