The short-term safety and efficacy of TANDEM microspheres of various sizes and doxorubicin loading concentrations for hepatocellular carcinoma treatment
Abstract Drug-eluting bead transarterial chemoembolization (DEB-TACE) is the most common treatment for unresectable hepatocellular carcinoma (HCC). However, the effect of drug loading concentration and microsphere size on treatment outcomes remains unclear. This retrospective study compares the outc...
Guardado en:
| Autores principales: | , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/cdb7ad7023744152ac9fb8ba2ba147e4 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:cdb7ad7023744152ac9fb8ba2ba147e4 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:cdb7ad7023744152ac9fb8ba2ba147e42021-12-02T15:02:52ZThe short-term safety and efficacy of TANDEM microspheres of various sizes and doxorubicin loading concentrations for hepatocellular carcinoma treatment10.1038/s41598-021-91021-92045-2322https://doaj.org/article/cdb7ad7023744152ac9fb8ba2ba147e42021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91021-9https://doaj.org/toc/2045-2322Abstract Drug-eluting bead transarterial chemoembolization (DEB-TACE) is the most common treatment for unresectable hepatocellular carcinoma (HCC). However, the effect of drug loading concentration and microsphere size on treatment outcomes remains unclear. This retrospective study compares the outcomes of 87 HCC patients who underwent DEB-TACE with half-loaded or full-loaded doxorubicin (maximum capacity 50 mg/mL) in 75-µm or 100-µm microspheres. Treatment with 100-μm microspheres resulted in significantly lower rates of procedure-related complications (6.6% vs. 26.9%; P < 0.05), post-embolization syndrome (32.8% vs. 61.5%, P < 0.05), SIR complications (32.8% vs. 61.5%; P < 0.01) and adverse events involving abdominal pain (19.7% vs. 42.3%; P < 0.05). Half-load doxorubicin microspheres resulted in greater treatment response (OR, 4.00; 95% CI 1.06–15.13; P, 0.041) and shorter hospital stays (OR, − 1.72; 95% CI − 2.77–0.68; P, 0.001) than did microspheres loaded to full capacity. Stratified analysis further showed that patients treated with 100-μm half-load doxorubicin microspheres had a higher CR (63.6% vs 18.0%) and ORR (90.9 vs 54.0%) and a shorter hospital stay (1.6 ± 1.3 vs 4.2 ± 2.3 days) than did those treated with full-load microspheres (P < 0.05). Thus, the drug-loading concentration of microspheres in DEB-TACE should be carefully considered.Chia-Ying LinYi-Sheng LiuKuang-Tse PanChia-Bang ChenChein-Fu HungChen-Te ChouNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Chia-Ying Lin Yi-Sheng Liu Kuang-Tse Pan Chia-Bang Chen Chein-Fu Hung Chen-Te Chou The short-term safety and efficacy of TANDEM microspheres of various sizes and doxorubicin loading concentrations for hepatocellular carcinoma treatment |
| description |
Abstract Drug-eluting bead transarterial chemoembolization (DEB-TACE) is the most common treatment for unresectable hepatocellular carcinoma (HCC). However, the effect of drug loading concentration and microsphere size on treatment outcomes remains unclear. This retrospective study compares the outcomes of 87 HCC patients who underwent DEB-TACE with half-loaded or full-loaded doxorubicin (maximum capacity 50 mg/mL) in 75-µm or 100-µm microspheres. Treatment with 100-μm microspheres resulted in significantly lower rates of procedure-related complications (6.6% vs. 26.9%; P < 0.05), post-embolization syndrome (32.8% vs. 61.5%, P < 0.05), SIR complications (32.8% vs. 61.5%; P < 0.01) and adverse events involving abdominal pain (19.7% vs. 42.3%; P < 0.05). Half-load doxorubicin microspheres resulted in greater treatment response (OR, 4.00; 95% CI 1.06–15.13; P, 0.041) and shorter hospital stays (OR, − 1.72; 95% CI − 2.77–0.68; P, 0.001) than did microspheres loaded to full capacity. Stratified analysis further showed that patients treated with 100-μm half-load doxorubicin microspheres had a higher CR (63.6% vs 18.0%) and ORR (90.9 vs 54.0%) and a shorter hospital stay (1.6 ± 1.3 vs 4.2 ± 2.3 days) than did those treated with full-load microspheres (P < 0.05). Thus, the drug-loading concentration of microspheres in DEB-TACE should be carefully considered. |
| format |
article |
| author |
Chia-Ying Lin Yi-Sheng Liu Kuang-Tse Pan Chia-Bang Chen Chein-Fu Hung Chen-Te Chou |
| author_facet |
Chia-Ying Lin Yi-Sheng Liu Kuang-Tse Pan Chia-Bang Chen Chein-Fu Hung Chen-Te Chou |
| author_sort |
Chia-Ying Lin |
| title |
The short-term safety and efficacy of TANDEM microspheres of various sizes and doxorubicin loading concentrations for hepatocellular carcinoma treatment |
| title_short |
The short-term safety and efficacy of TANDEM microspheres of various sizes and doxorubicin loading concentrations for hepatocellular carcinoma treatment |
| title_full |
The short-term safety and efficacy of TANDEM microspheres of various sizes and doxorubicin loading concentrations for hepatocellular carcinoma treatment |
| title_fullStr |
The short-term safety and efficacy of TANDEM microspheres of various sizes and doxorubicin loading concentrations for hepatocellular carcinoma treatment |
| title_full_unstemmed |
The short-term safety and efficacy of TANDEM microspheres of various sizes and doxorubicin loading concentrations for hepatocellular carcinoma treatment |
| title_sort |
short-term safety and efficacy of tandem microspheres of various sizes and doxorubicin loading concentrations for hepatocellular carcinoma treatment |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/cdb7ad7023744152ac9fb8ba2ba147e4 |
| work_keys_str_mv |
AT chiayinglin theshorttermsafetyandefficacyoftandemmicrospheresofvarioussizesanddoxorubicinloadingconcentrationsforhepatocellularcarcinomatreatment AT yishengliu theshorttermsafetyandefficacyoftandemmicrospheresofvarioussizesanddoxorubicinloadingconcentrationsforhepatocellularcarcinomatreatment AT kuangtsepan theshorttermsafetyandefficacyoftandemmicrospheresofvarioussizesanddoxorubicinloadingconcentrationsforhepatocellularcarcinomatreatment AT chiabangchen theshorttermsafetyandefficacyoftandemmicrospheresofvarioussizesanddoxorubicinloadingconcentrationsforhepatocellularcarcinomatreatment AT cheinfuhung theshorttermsafetyandefficacyoftandemmicrospheresofvarioussizesanddoxorubicinloadingconcentrationsforhepatocellularcarcinomatreatment AT chentechou theshorttermsafetyandefficacyoftandemmicrospheresofvarioussizesanddoxorubicinloadingconcentrationsforhepatocellularcarcinomatreatment AT chiayinglin shorttermsafetyandefficacyoftandemmicrospheresofvarioussizesanddoxorubicinloadingconcentrationsforhepatocellularcarcinomatreatment AT yishengliu shorttermsafetyandefficacyoftandemmicrospheresofvarioussizesanddoxorubicinloadingconcentrationsforhepatocellularcarcinomatreatment AT kuangtsepan shorttermsafetyandefficacyoftandemmicrospheresofvarioussizesanddoxorubicinloadingconcentrationsforhepatocellularcarcinomatreatment AT chiabangchen shorttermsafetyandefficacyoftandemmicrospheresofvarioussizesanddoxorubicinloadingconcentrationsforhepatocellularcarcinomatreatment AT cheinfuhung shorttermsafetyandefficacyoftandemmicrospheresofvarioussizesanddoxorubicinloadingconcentrationsforhepatocellularcarcinomatreatment AT chentechou shorttermsafetyandefficacyoftandemmicrospheresofvarioussizesanddoxorubicinloadingconcentrationsforhepatocellularcarcinomatreatment |
| _version_ |
1718389104918396928 |