Update on genetics and diabetic retinopathy

Blake M Hampton,1 Stephen G Schwartz,1 Milam A Brantley Jr,2 Harry W Flynn Jr1 1Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA; 2Department of Ophthalmology, Vanderbilt Eye Institute, Nashville, TN, USA Abstract: Clinical ris...

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Autores principales:	Hampton BM, Schwartz SG, Brantley MA Jr, Flynn HW Jr
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/cdc0d06b9a8348d89e11f35affcb599d
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spelling	oai:doaj.org-article:cdc0d06b9a8348d89e11f35affcb599d2021-12-02T05:49:47ZUpdate on genetics and diabetic retinopathy1177-5483https://doaj.org/article/cdc0d06b9a8348d89e11f35affcb599d2015-11-01T00:00:00Zhttps://www.dovepress.com/update-on-genetics-and-diabetic-retinopathy-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Blake M Hampton,1 Stephen G Schwartz,1 Milam A Brantley Jr,2 Harry W Flynn Jr1 1Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA; 2Department of Ophthalmology, Vanderbilt Eye Institute, Nashville, TN, USA Abstract: Clinical risk factors for diabetic retinopathy (DR), such as duration of disease and degree of glucose control, do not adequately predict disease progression in individual patients, suggesting the presence of a genetic component. Multiple smaller studies have investigated genotype–phenotype correlations in genes encoding vascular endothelial growth factor, aldose reductase, the receptor for advanced glycation end products, and many others. In general, reported results have been conflicting, due to factors including small sample sizes, variations in study design, differences in clinical end points, and underlying genetic differences between study groups. At this time, there is no confirmed association with any risk allele reported. As we continue to collect data from additional studies, the role of genetics in DR may become more apparent. Keywords: diabetic retinopathy, genetics, single nucleotide polymorphism, genome-wide association studyHampton BMSchwartz SGBrantley MA JrFlynn HW JrDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2015, Iss default, Pp 2175-2193 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Hampton BM Schwartz SG Brantley MA Jr Flynn HW Jr Update on genetics and diabetic retinopathy
description	Blake M Hampton,1 Stephen G Schwartz,1 Milam A Brantley Jr,2 Harry W Flynn Jr1 1Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA; 2Department of Ophthalmology, Vanderbilt Eye Institute, Nashville, TN, USA Abstract: Clinical risk factors for diabetic retinopathy (DR), such as duration of disease and degree of glucose control, do not adequately predict disease progression in individual patients, suggesting the presence of a genetic component. Multiple smaller studies have investigated genotype–phenotype correlations in genes encoding vascular endothelial growth factor, aldose reductase, the receptor for advanced glycation end products, and many others. In general, reported results have been conflicting, due to factors including small sample sizes, variations in study design, differences in clinical end points, and underlying genetic differences between study groups. At this time, there is no confirmed association with any risk allele reported. As we continue to collect data from additional studies, the role of genetics in DR may become more apparent. Keywords: diabetic retinopathy, genetics, single nucleotide polymorphism, genome-wide association study
format	article
author	Hampton BM Schwartz SG Brantley MA Jr Flynn HW Jr
author_facet	Hampton BM Schwartz SG Brantley MA Jr Flynn HW Jr
author_sort	Hampton BM
title	Update on genetics and diabetic retinopathy
title_short	Update on genetics and diabetic retinopathy
title_full	Update on genetics and diabetic retinopathy
title_fullStr	Update on genetics and diabetic retinopathy
title_full_unstemmed	Update on genetics and diabetic retinopathy
title_sort	update on genetics and diabetic retinopathy
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/cdc0d06b9a8348d89e11f35affcb599d
work_keys_str_mv	AT hamptonbm updateongeneticsanddiabeticretinopathy AT schwartzsg updateongeneticsanddiabeticretinopathy AT brantleymajr updateongeneticsanddiabeticretinopathy AT flynnhwjr updateongeneticsanddiabeticretinopathy
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Update on genetics and diabetic retinopathy

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