Use of CRISPR-Cas9 To Target Homologous Recombination Limits Transformation-Induced Genomic Changes in <named-content content-type="genus-species">Candida albicans</named-content>

Use of CRISPR-Cas9 To Target Homologous Recombination Limits Transformation-Induced Genomic Changes in <named-content content-type="genus-species">Candida albicans</named-content>

ABSTRACT Most of our knowledge relating to molecular mechanisms of human fungal pathogenesis in Candida albicans relies on reverse genetics approaches, requiring strain engineering. DNA-mediated transformation of C. albicans has been described as highly mutagenic, potentially accentuated by the orga...

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Autores principales: Timea Marton, Corinne Maufrais, Christophe d’Enfert, Melanie Legrand
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2020
Materias:
CRISPR-Cas9
Candida albicans
genome rearrangements
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/cdc40270ef2740f2a5459b3e3b97d217
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