Resistance to TGFβ suppression and improved anti-tumor responses in CD8+ T cells lacking PTPN22

TGFβ secretion in the tumor microenvironment inhibits T cell-mediated anti-tumor immune responses. Here the authors show that a mutation predisposing to autoimmune diseases confers T cells resistance to TGFβ inhibitory action and could be exploited to engineer immunotherapies for TGFβ secreting tumo...

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Autores principales:	Rebecca J. Brownlie, Celine Garcia, Mate Ravasz, Dietmar Zehn, Robert J. Salmond, Rose Zamoyska
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cdc63d275db74abeb71860f4aa4a1656
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spelling	oai:doaj.org-article:cdc63d275db74abeb71860f4aa4a16562021-12-02T14:40:36ZResistance to TGFβ suppression and improved anti-tumor responses in CD8+ T cells lacking PTPN2210.1038/s41467-017-01427-12041-1723https://doaj.org/article/cdc63d275db74abeb71860f4aa4a16562017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01427-1https://doaj.org/toc/2041-1723TGFβ secretion in the tumor microenvironment inhibits T cell-mediated anti-tumor immune responses. Here the authors show that a mutation predisposing to autoimmune diseases confers T cells resistance to TGFβ inhibitory action and could be exploited to engineer immunotherapies for TGFβ secreting tumors.Rebecca J. BrownlieCeline GarciaMate RavaszDietmar ZehnRobert J. SalmondRose ZamoyskaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rebecca J. Brownlie Celine Garcia Mate Ravasz Dietmar Zehn Robert J. Salmond Rose Zamoyska Resistance to TGFβ suppression and improved anti-tumor responses in CD8+ T cells lacking PTPN22
description	TGFβ secretion in the tumor microenvironment inhibits T cell-mediated anti-tumor immune responses. Here the authors show that a mutation predisposing to autoimmune diseases confers T cells resistance to TGFβ inhibitory action and could be exploited to engineer immunotherapies for TGFβ secreting tumors.
format	article
author	Rebecca J. Brownlie Celine Garcia Mate Ravasz Dietmar Zehn Robert J. Salmond Rose Zamoyska
author_facet	Rebecca J. Brownlie Celine Garcia Mate Ravasz Dietmar Zehn Robert J. Salmond Rose Zamoyska
author_sort	Rebecca J. Brownlie
title	Resistance to TGFβ suppression and improved anti-tumor responses in CD8+ T cells lacking PTPN22
title_short	Resistance to TGFβ suppression and improved anti-tumor responses in CD8+ T cells lacking PTPN22
title_full	Resistance to TGFβ suppression and improved anti-tumor responses in CD8+ T cells lacking PTPN22
title_fullStr	Resistance to TGFβ suppression and improved anti-tumor responses in CD8+ T cells lacking PTPN22
title_full_unstemmed	Resistance to TGFβ suppression and improved anti-tumor responses in CD8+ T cells lacking PTPN22
title_sort	resistance to tgfβ suppression and improved anti-tumor responses in cd8+ t cells lacking ptpn22
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/cdc63d275db74abeb71860f4aa4a1656
work_keys_str_mv	AT rebeccajbrownlie resistancetotgfbsuppressionandimprovedantitumorresponsesincd8tcellslackingptpn22 AT celinegarcia resistancetotgfbsuppressionandimprovedantitumorresponsesincd8tcellslackingptpn22 AT materavasz resistancetotgfbsuppressionandimprovedantitumorresponsesincd8tcellslackingptpn22 AT dietmarzehn resistancetotgfbsuppressionandimprovedantitumorresponsesincd8tcellslackingptpn22 AT robertjsalmond resistancetotgfbsuppressionandimprovedantitumorresponsesincd8tcellslackingptpn22 AT rosezamoyska resistancetotgfbsuppressionandimprovedantitumorresponsesincd8tcellslackingptpn22
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Resistance to TGFβ suppression and improved anti-tumor responses in CD8+ T cells lacking PTPN22

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