Resistance to TGFβ suppression and improved anti-tumor responses in CD8+ T cells lacking PTPN22

TGFβ secretion in the tumor microenvironment inhibits T cell-mediated anti-tumor immune responses. Here the authors show that a mutation predisposing to autoimmune diseases confers T cells resistance to TGFβ inhibitory action and could be exploited to engineer immunotherapies for TGFβ secreting tumo...

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Autores principales: Rebecca J. Brownlie, Celine Garcia, Mate Ravasz, Dietmar Zehn, Robert J. Salmond, Rose Zamoyska
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/cdc63d275db74abeb71860f4aa4a1656
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