Neuronal sFlt1 and Vegfaa determine venous sprouting and spinal cord vascularization

Neuronal sFlt1 and Vegfaa determine venous sprouting and spinal cord vascularization

The generation of vasculature in organs is regulated by cross-talk between the developing tissue and specialized endothelial cells. Here, the authors show that vessel growth feeding the zebrafish spinal cord is coordinated by balancing neuron-derived pro-angiogenic ligand Vegfaa and its receptor, sF...

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Autores principales: Raphael Wild, Alina Klems, Masanari Takamiya, Yuya Hayashi, Uwe Strähle, Koji Ando, Naoki Mochizuki, Andreas van Impel, Stefan Schulte-Merker, Janna Krueger, Laetitia Preau, Ferdinand le Noble
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Science
Q
Acceso en línea:https://doaj.org/article/cdc7bf090b8e4a769873ee7f421be5b1
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spelling oai:doaj.org-article:cdc7bf090b8e4a769873ee7f421be5b12021-12-02T14:42:22ZNeuronal sFlt1 and Vegfaa determine venous sprouting and spinal cord vascularization10.1038/ncomms139912041-1723https://doaj.org/article/cdc7bf090b8e4a769873ee7f421be5b12017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms13991https://doaj.org/toc/2041-1723The generation of vasculature in organs is regulated by cross-talk between the developing tissue and specialized endothelial cells. Here, the authors show that vessel growth feeding the zebrafish spinal cord is coordinated by balancing neuron-derived pro-angiogenic ligand Vegfaa and its receptor, sFlt1.Raphael WildAlina KlemsMasanari TakamiyaYuya HayashiUwe SträhleKoji AndoNaoki MochizukiAndreas van ImpelStefan Schulte-MerkerJanna KruegerLaetitia PreauFerdinand le NobleNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Raphael Wild
Alina Klems
Masanari Takamiya
Yuya Hayashi
Uwe Strähle
Koji Ando
Naoki Mochizuki
Andreas van Impel
Stefan Schulte-Merker
Janna Krueger
Laetitia Preau
Ferdinand le Noble
Neuronal sFlt1 and Vegfaa determine venous sprouting and spinal cord vascularization
description The generation of vasculature in organs is regulated by cross-talk between the developing tissue and specialized endothelial cells. Here, the authors show that vessel growth feeding the zebrafish spinal cord is coordinated by balancing neuron-derived pro-angiogenic ligand Vegfaa and its receptor, sFlt1.
format article
author Raphael Wild
Alina Klems
Masanari Takamiya
Yuya Hayashi
Uwe Strähle
Koji Ando
Naoki Mochizuki
Andreas van Impel
Stefan Schulte-Merker
Janna Krueger
Laetitia Preau
Ferdinand le Noble
author_facet Raphael Wild
Alina Klems
Masanari Takamiya
Yuya Hayashi
Uwe Strähle
Koji Ando
Naoki Mochizuki
Andreas van Impel
Stefan Schulte-Merker
Janna Krueger
Laetitia Preau
Ferdinand le Noble
author_sort Raphael Wild
title Neuronal sFlt1 and Vegfaa determine venous sprouting and spinal cord vascularization
title_short Neuronal sFlt1 and Vegfaa determine venous sprouting and spinal cord vascularization
title_full Neuronal sFlt1 and Vegfaa determine venous sprouting and spinal cord vascularization
title_fullStr Neuronal sFlt1 and Vegfaa determine venous sprouting and spinal cord vascularization
title_full_unstemmed Neuronal sFlt1 and Vegfaa determine venous sprouting and spinal cord vascularization
title_sort neuronal sflt1 and vegfaa determine venous sprouting and spinal cord vascularization
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/cdc7bf090b8e4a769873ee7f421be5b1
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AT yuyahayashi neuronalsflt1andvegfaadeterminevenoussproutingandspinalcordvascularization
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