ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism

The fusion gene ZMYND11-MBTD1 (ZM) is present in a subgroup of patients with acute myeloid leukaemia (AML). Here, the authors show that ZM expression induces AML in a murine model though activating the NuA4/TIP60 histone acetyltransferase complex.

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Autores principales:	Jie Li, Phillip M. Galbo, Weida Gong, Aaron J. Storey, Yi-Hsuan Tsai, Xufen Yu, Jeong Hyun Ahn, Yiran Guo, Samuel G. Mackintosh, Ricky D. Edmondson, Stephanie D. Byrum, Jason E. Farrar, Shenghui He, Ling Cai, Jian Jin, Alan J. Tackett, Deyou Zheng, Gang Greg Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cdcc2ab94850477c835abe99c9bfa857
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spelling	oai:doaj.org-article:cdcc2ab94850477c835abe99c9bfa8572021-12-02T14:21:24ZZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism10.1038/s41467-021-21357-32041-1723https://doaj.org/article/cdcc2ab94850477c835abe99c9bfa8572021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21357-3https://doaj.org/toc/2041-1723The fusion gene ZMYND11-MBTD1 (ZM) is present in a subgroup of patients with acute myeloid leukaemia (AML). Here, the authors show that ZM expression induces AML in a murine model though activating the NuA4/TIP60 histone acetyltransferase complex.Jie LiPhillip M. GalboWeida GongAaron J. StoreyYi-Hsuan TsaiXufen YuJeong Hyun AhnYiran GuoSamuel G. MackintoshRicky D. EdmondsonStephanie D. ByrumJason E. FarrarShenghui HeLing CaiJian JinAlan J. TackettDeyou ZhengGang Greg WangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jie Li Phillip M. Galbo Weida Gong Aaron J. Storey Yi-Hsuan Tsai Xufen Yu Jeong Hyun Ahn Yiran Guo Samuel G. Mackintosh Ricky D. Edmondson Stephanie D. Byrum Jason E. Farrar Shenghui He Ling Cai Jian Jin Alan J. Tackett Deyou Zheng Gang Greg Wang ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism
description	The fusion gene ZMYND11-MBTD1 (ZM) is present in a subgroup of patients with acute myeloid leukaemia (AML). Here, the authors show that ZM expression induces AML in a murine model though activating the NuA4/TIP60 histone acetyltransferase complex.
format	article
author	Jie Li Phillip M. Galbo Weida Gong Aaron J. Storey Yi-Hsuan Tsai Xufen Yu Jeong Hyun Ahn Yiran Guo Samuel G. Mackintosh Ricky D. Edmondson Stephanie D. Byrum Jason E. Farrar Shenghui He Ling Cai Jian Jin Alan J. Tackett Deyou Zheng Gang Greg Wang
author_facet	Jie Li Phillip M. Galbo Weida Gong Aaron J. Storey Yi-Hsuan Tsai Xufen Yu Jeong Hyun Ahn Yiran Guo Samuel G. Mackintosh Ricky D. Edmondson Stephanie D. Byrum Jason E. Farrar Shenghui He Ling Cai Jian Jin Alan J. Tackett Deyou Zheng Gang Greg Wang
author_sort	Jie Li
title	ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism
title_short	ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism
title_full	ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism
title_fullStr	ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism
title_full_unstemmed	ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism
title_sort	zmynd11-mbtd1 induces leukemogenesis through hijacking nua4/tip60 acetyltransferase complex and a pwwp-mediated chromatin association mechanism
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/cdcc2ab94850477c835abe99c9bfa857
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ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism

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