Prognostic value of E-Cadherin and its tumor suppressor role in Saudi women with advanced epithelial ovarian cancer

The extracellular matrix (ECM) disruption and cytoskeleton reorganization are crucial events in tumor proliferation and invasion. E-Cadherin (E-CAD) is a member of cell adhesion molecules involved in cell-cell junctions and ECM stability. The loss of E-CAD expression is associated with cancer progre...

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Autores principales:	Mourad Assidi, Mohammad Alam Jafri, Muhammad Abu-Elmagd, Peter N. Pushparaj, Salina Saddick, Safia Messaoudi, Heba Alkhatabi, Jaudah Al-Maghrabi, Nisreen Anfinan, Maram Sait, Abdelfatteh El Omri, Hesham Sait, Hussain Basalamah, Abdelbaset Buhmeida, Khalid Sait
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	e-cadherin ovarian cancer prognostic value immunohistochemistry tissue microarray Medicine R
Acceso en línea:	https://doaj.org/article/cdd22f7ef92a4c7aa3fc8c2fffbfafd2
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spelling	oai:doaj.org-article:cdd22f7ef92a4c7aa3fc8c2fffbfafd22021-11-26T11:19:48ZPrognostic value of E-Cadherin and its tumor suppressor role in Saudi women with advanced epithelial ovarian cancer1993-28201819-635710.1080/19932820.2021.1994741https://doaj.org/article/cdd22f7ef92a4c7aa3fc8c2fffbfafd22021-01-01T00:00:00Zhttp://dx.doi.org/10.1080/19932820.2021.1994741https://doaj.org/toc/1993-2820https://doaj.org/toc/1819-6357The extracellular matrix (ECM) disruption and cytoskeleton reorganization are crucial events in tumor proliferation and invasion. E-Cadherin (E-CAD) is a member of cell adhesion molecules involved in cell-cell junctions and ECM stability. The loss of E-CAD expression is associated with cancer progression and metastasis. This retrospective study aimed to assess E-CAD protein expression in ovarian cancer (OC) tissues and to evaluate its prognostic value. Patients and Methods: 143 formalin-fixed and paraffin-embedded (FFPE) blocks of primary advanced stages OC were retrieved and used to construct Tissue microarrays. Automated immunohistochemistry technique was performed to evaluate E-CAD protein expression patterns in OC. Results: E-CAD protein expression was significantly correlated with OC histological subtype (p < 0.0001), while borderline significant correlations were observed with both tumor grade (p = 0.06) and stage (p = 0.07). Interestingly, Kaplan-Meier survival analysis showed that OC patients with membranous E-CAD expression survived longer than those with no E-CAD expression mainly those at advanced stages (p < 0.009). Further in silico analysis confirms the key roles of E-CAD in OC molecular functions. Conclusion: we reported a prognosis value of membranous E-CAD in advanced stage OC patients. Further validation using larger cohorts is recommended to extract clinically relevant outcomes towards better OC management and individualized oncology.Mourad AssidiMohammad Alam JafriMuhammad Abu-ElmagdPeter N. PushparajSalina SaddickSafia MessaoudiHeba AlkhatabiJaudah Al-MaghrabiNisreen AnfinanMaram SaitAbdelfatteh El OmriHesham SaitHussain BasalamahAbdelbaset BuhmeidaKhalid SaitTaylor & Francis Grouparticlee-cadherinovarian cancerprognostic valueimmunohistochemistrytissue microarrayMedicineRENLibyan Journal of Medicine, Vol 16, Iss 1 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	e-cadherin ovarian cancer prognostic value immunohistochemistry tissue microarray Medicine R
spellingShingle	e-cadherin ovarian cancer prognostic value immunohistochemistry tissue microarray Medicine R Mourad Assidi Mohammad Alam Jafri Muhammad Abu-Elmagd Peter N. Pushparaj Salina Saddick Safia Messaoudi Heba Alkhatabi Jaudah Al-Maghrabi Nisreen Anfinan Maram Sait Abdelfatteh El Omri Hesham Sait Hussain Basalamah Abdelbaset Buhmeida Khalid Sait Prognostic value of E-Cadherin and its tumor suppressor role in Saudi women with advanced epithelial ovarian cancer
description	The extracellular matrix (ECM) disruption and cytoskeleton reorganization are crucial events in tumor proliferation and invasion. E-Cadherin (E-CAD) is a member of cell adhesion molecules involved in cell-cell junctions and ECM stability. The loss of E-CAD expression is associated with cancer progression and metastasis. This retrospective study aimed to assess E-CAD protein expression in ovarian cancer (OC) tissues and to evaluate its prognostic value. Patients and Methods: 143 formalin-fixed and paraffin-embedded (FFPE) blocks of primary advanced stages OC were retrieved and used to construct Tissue microarrays. Automated immunohistochemistry technique was performed to evaluate E-CAD protein expression patterns in OC. Results: E-CAD protein expression was significantly correlated with OC histological subtype (p < 0.0001), while borderline significant correlations were observed with both tumor grade (p = 0.06) and stage (p = 0.07). Interestingly, Kaplan-Meier survival analysis showed that OC patients with membranous E-CAD expression survived longer than those with no E-CAD expression mainly those at advanced stages (p < 0.009). Further in silico analysis confirms the key roles of E-CAD in OC molecular functions. Conclusion: we reported a prognosis value of membranous E-CAD in advanced stage OC patients. Further validation using larger cohorts is recommended to extract clinically relevant outcomes towards better OC management and individualized oncology.
format	article
author	Mourad Assidi Mohammad Alam Jafri Muhammad Abu-Elmagd Peter N. Pushparaj Salina Saddick Safia Messaoudi Heba Alkhatabi Jaudah Al-Maghrabi Nisreen Anfinan Maram Sait Abdelfatteh El Omri Hesham Sait Hussain Basalamah Abdelbaset Buhmeida Khalid Sait
author_facet	Mourad Assidi Mohammad Alam Jafri Muhammad Abu-Elmagd Peter N. Pushparaj Salina Saddick Safia Messaoudi Heba Alkhatabi Jaudah Al-Maghrabi Nisreen Anfinan Maram Sait Abdelfatteh El Omri Hesham Sait Hussain Basalamah Abdelbaset Buhmeida Khalid Sait
author_sort	Mourad Assidi
title	Prognostic value of E-Cadherin and its tumor suppressor role in Saudi women with advanced epithelial ovarian cancer
title_short	Prognostic value of E-Cadherin and its tumor suppressor role in Saudi women with advanced epithelial ovarian cancer
title_full	Prognostic value of E-Cadherin and its tumor suppressor role in Saudi women with advanced epithelial ovarian cancer
title_fullStr	Prognostic value of E-Cadherin and its tumor suppressor role in Saudi women with advanced epithelial ovarian cancer
title_full_unstemmed	Prognostic value of E-Cadherin and its tumor suppressor role in Saudi women with advanced epithelial ovarian cancer
title_sort	prognostic value of e-cadherin and its tumor suppressor role in saudi women with advanced epithelial ovarian cancer
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/cdd22f7ef92a4c7aa3fc8c2fffbfafd2
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Prognostic value of E-Cadherin and its tumor suppressor role in Saudi women with advanced epithelial ovarian cancer

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