Quantitating the epigenetic transformation contributing to cholesterol homeostasis using Gaussian process

How epigenetics coordinate with genetics to impact protein fitness is unknown. Here, using a Variation Spatial Profiling strategy and machine learning, the authors map HDAC impact on a full set of Niemann pick C1 disease variants to quantitate an unanticipated plasticity in central dogma.

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Autores principales:	Chao Wang, Samantha M. Scott, Kanagaraj Subramanian, Salvatore Loguercio, Pei Zhao, Darren M. Hutt, Nicole Y. Farhat, Forbes D. Porter, William E. Balch
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cdd46cddd7bd45bbba719375caab04d4
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spelling	oai:doaj.org-article:cdd46cddd7bd45bbba719375caab04d42021-12-02T17:31:22ZQuantitating the epigenetic transformation contributing to cholesterol homeostasis using Gaussian process10.1038/s41467-019-12969-x2041-1723https://doaj.org/article/cdd46cddd7bd45bbba719375caab04d42019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12969-xhttps://doaj.org/toc/2041-1723How epigenetics coordinate with genetics to impact protein fitness is unknown. Here, using a Variation Spatial Profiling strategy and machine learning, the authors map HDAC impact on a full set of Niemann pick C1 disease variants to quantitate an unanticipated plasticity in central dogma.Chao WangSamantha M. ScottKanagaraj SubramanianSalvatore LoguercioPei ZhaoDarren M. HuttNicole Y. FarhatForbes D. PorterWilliam E. BalchNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chao Wang Samantha M. Scott Kanagaraj Subramanian Salvatore Loguercio Pei Zhao Darren M. Hutt Nicole Y. Farhat Forbes D. Porter William E. Balch Quantitating the epigenetic transformation contributing to cholesterol homeostasis using Gaussian process
description	How epigenetics coordinate with genetics to impact protein fitness is unknown. Here, using a Variation Spatial Profiling strategy and machine learning, the authors map HDAC impact on a full set of Niemann pick C1 disease variants to quantitate an unanticipated plasticity in central dogma.
format	article
author	Chao Wang Samantha M. Scott Kanagaraj Subramanian Salvatore Loguercio Pei Zhao Darren M. Hutt Nicole Y. Farhat Forbes D. Porter William E. Balch
author_facet	Chao Wang Samantha M. Scott Kanagaraj Subramanian Salvatore Loguercio Pei Zhao Darren M. Hutt Nicole Y. Farhat Forbes D. Porter William E. Balch
author_sort	Chao Wang
title	Quantitating the epigenetic transformation contributing to cholesterol homeostasis using Gaussian process
title_short	Quantitating the epigenetic transformation contributing to cholesterol homeostasis using Gaussian process
title_full	Quantitating the epigenetic transformation contributing to cholesterol homeostasis using Gaussian process
title_fullStr	Quantitating the epigenetic transformation contributing to cholesterol homeostasis using Gaussian process
title_full_unstemmed	Quantitating the epigenetic transformation contributing to cholesterol homeostasis using Gaussian process
title_sort	quantitating the epigenetic transformation contributing to cholesterol homeostasis using gaussian process
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/cdd46cddd7bd45bbba719375caab04d4
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Quantitating the epigenetic transformation contributing to cholesterol homeostasis using Gaussian process

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