Structure of tRNA splicing enzyme Tpt1 illuminates the mechanism of RNA 2′-PO4 recognition and ADP-ribosylation
Tpt1 catalyzes the final essential step in yeast tRNA splicing and is a potential antifungal target. Here the authors provide structural insights into how Tpt1 recognizes a 2’-PO4 RNA splice junction and the mechanism of RNA phospho-ADP-ribosylation.
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Nature Portfolio
2019
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oai:doaj.org-article:cdd75b7ad930479491bcd6cb6ab919512021-12-02T14:39:02ZStructure of tRNA splicing enzyme Tpt1 illuminates the mechanism of RNA 2′-PO4 recognition and ADP-ribosylation10.1038/s41467-018-08211-92041-1723https://doaj.org/article/cdd75b7ad930479491bcd6cb6ab919512019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08211-9https://doaj.org/toc/2041-1723Tpt1 catalyzes the final essential step in yeast tRNA splicing and is a potential antifungal target. Here the authors provide structural insights into how Tpt1 recognizes a 2’-PO4 RNA splice junction and the mechanism of RNA phospho-ADP-ribosylation.Ankan BanerjeeAnnum MunirLeonora AbdullahuMasad J. DamhaYehuda GoldgurStewart ShumanNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
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Science Q Ankan Banerjee Annum Munir Leonora Abdullahu Masad J. Damha Yehuda Goldgur Stewart Shuman Structure of tRNA splicing enzyme Tpt1 illuminates the mechanism of RNA 2′-PO4 recognition and ADP-ribosylation |
| description |
Tpt1 catalyzes the final essential step in yeast tRNA splicing and is a potential antifungal target. Here the authors provide structural insights into how Tpt1 recognizes a 2’-PO4 RNA splice junction and the mechanism of RNA phospho-ADP-ribosylation. |
| format |
article |
| author |
Ankan Banerjee Annum Munir Leonora Abdullahu Masad J. Damha Yehuda Goldgur Stewart Shuman |
| author_facet |
Ankan Banerjee Annum Munir Leonora Abdullahu Masad J. Damha Yehuda Goldgur Stewart Shuman |
| author_sort |
Ankan Banerjee |
| title |
Structure of tRNA splicing enzyme Tpt1 illuminates the mechanism of RNA 2′-PO4 recognition and ADP-ribosylation |
| title_short |
Structure of tRNA splicing enzyme Tpt1 illuminates the mechanism of RNA 2′-PO4 recognition and ADP-ribosylation |
| title_full |
Structure of tRNA splicing enzyme Tpt1 illuminates the mechanism of RNA 2′-PO4 recognition and ADP-ribosylation |
| title_fullStr |
Structure of tRNA splicing enzyme Tpt1 illuminates the mechanism of RNA 2′-PO4 recognition and ADP-ribosylation |
| title_full_unstemmed |
Structure of tRNA splicing enzyme Tpt1 illuminates the mechanism of RNA 2′-PO4 recognition and ADP-ribosylation |
| title_sort |
structure of trna splicing enzyme tpt1 illuminates the mechanism of rna 2′-po4 recognition and adp-ribosylation |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/cdd75b7ad930479491bcd6cb6ab91951 |
| work_keys_str_mv |
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| _version_ |
1718390797828620288 |