Loss of microglial SIRPα promotes synaptic pruning in preclinical models of neurodegeneration

Loss of microglial SIRPα promotes synaptic pruning in preclinical models of neurodegeneration

Microglial SIRPα regulates synaptic pruning during development. Its role in neurodegeneration is unclear. Here, the authors show microglial SIRPα declines in the model of Alzheimer’s disease, leading to excessive microglia mediated synapse elimination as well as impaired cognitive function.

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Bibliographic Details
Main Authors: Xin Ding, Jin Wang, Miaoxin Huang, Zhangpeng Chen, Jing Liu, Qipeng Zhang, Chenyu Zhang, Yang Xiang, Ke Zen, Liang Li
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Science
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Online Access:https://doaj.org/article/cdd81fefeab84962a6ea3d4a15657384
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spelling oai:doaj.org-article:cdd81fefeab84962a6ea3d4a156573842021-12-02T13:26:23ZLoss of microglial SIRPα promotes synaptic pruning in preclinical models of neurodegeneration10.1038/s41467-021-22301-12041-1723https://doaj.org/article/cdd81fefeab84962a6ea3d4a156573842021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22301-1https://doaj.org/toc/2041-1723Microglial SIRPα regulates synaptic pruning during development. Its role in neurodegeneration is unclear. Here, the authors show microglial SIRPα declines in the model of Alzheimer’s disease, leading to excessive microglia mediated synapse elimination as well as impaired cognitive function.Xin DingJin WangMiaoxin HuangZhangpeng ChenJing LiuQipeng ZhangChenyu ZhangYang XiangKe ZenLiang LiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Xin Ding
Jin Wang
Miaoxin Huang
Zhangpeng Chen
Jing Liu
Qipeng Zhang
Chenyu Zhang
Yang Xiang
Ke Zen
Liang Li
Loss of microglial SIRPα promotes synaptic pruning in preclinical models of neurodegeneration
description Microglial SIRPα regulates synaptic pruning during development. Its role in neurodegeneration is unclear. Here, the authors show microglial SIRPα declines in the model of Alzheimer’s disease, leading to excessive microglia mediated synapse elimination as well as impaired cognitive function.
format article
author Xin Ding
Jin Wang
Miaoxin Huang
Zhangpeng Chen
Jing Liu
Qipeng Zhang
Chenyu Zhang
Yang Xiang
Ke Zen
Liang Li
author_facet Xin Ding
Jin Wang
Miaoxin Huang
Zhangpeng Chen
Jing Liu
Qipeng Zhang
Chenyu Zhang
Yang Xiang
Ke Zen
Liang Li
author_sort Xin Ding
title Loss of microglial SIRPα promotes synaptic pruning in preclinical models of neurodegeneration
title_short Loss of microglial SIRPα promotes synaptic pruning in preclinical models of neurodegeneration
title_full Loss of microglial SIRPα promotes synaptic pruning in preclinical models of neurodegeneration
title_fullStr Loss of microglial SIRPα promotes synaptic pruning in preclinical models of neurodegeneration
title_full_unstemmed Loss of microglial SIRPα promotes synaptic pruning in preclinical models of neurodegeneration
title_sort loss of microglial sirpα promotes synaptic pruning in preclinical models of neurodegeneration
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/cdd81fefeab84962a6ea3d4a15657384
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