Loss of microglial SIRPα promotes synaptic pruning in preclinical models of neurodegeneration

Loss of microglial SIRPα promotes synaptic pruning in preclinical models of neurodegeneration

Microglial SIRPα regulates synaptic pruning during development. Its role in neurodegeneration is unclear. Here, the authors show microglial SIRPα declines in the model of Alzheimer’s disease, leading to excessive microglia mediated synapse elimination as well as impaired cognitive function.

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Detalles Bibliográficos
Autores principales: Xin Ding, Jin Wang, Miaoxin Huang, Zhangpeng Chen, Jing Liu, Qipeng Zhang, Chenyu Zhang, Yang Xiang, Ke Zen, Liang Li
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Science
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Acceso en línea:https://doaj.org/article/cdd81fefeab84962a6ea3d4a15657384
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