Neonicotinoids disrupt memory, circadian behaviour and sleep

Abstract Globally, neonicotinoids are the most used insecticides, despite their well-documented sub-lethal effects on beneficial insects. Neonicotinoids are nicotinic acetylcholine receptor agonists. Memory, circadian rhythmicity and sleep are essential for efficient foraging and pollination and req...

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Autores principales:	Kiah Tasman, Sergio Hidalgo, Bangfu Zhu, Sean A. Rands, James J. L. Hodge
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cddb73eff2564c4b9fb52c8cbfc10153
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spelling	oai:doaj.org-article:cddb73eff2564c4b9fb52c8cbfc101532021-12-02T10:49:22ZNeonicotinoids disrupt memory, circadian behaviour and sleep10.1038/s41598-021-81548-22045-2322https://doaj.org/article/cddb73eff2564c4b9fb52c8cbfc101532021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81548-2https://doaj.org/toc/2045-2322Abstract Globally, neonicotinoids are the most used insecticides, despite their well-documented sub-lethal effects on beneficial insects. Neonicotinoids are nicotinic acetylcholine receptor agonists. Memory, circadian rhythmicity and sleep are essential for efficient foraging and pollination and require nicotinic acetylcholine receptor signalling. The effect of field-relevant concentrations of the European Union-banned neonicotinoids: imidacloprid, clothianidin, thiamethoxam and thiacloprid were tested on Drosophila memory, circadian rhythms and sleep. Field-relevant concentrations of imidacloprid, clothianidin and thiamethoxam disrupted learning, behavioural rhythmicity and sleep whilst thiacloprid exposure only affected sleep. Exposure to imidacloprid and clothianidin prevented the day/night remodelling and accumulation of pigment dispersing factor (PDF) neuropeptide in the dorsal terminals of clock neurons. Knockdown of the neonicotinoid susceptible Dα1 and Dβ2 nicotinic acetylcholine receptor subunits in the mushroom bodies or clock neurons recapitulated the neonicotinoid like deficits in memory or sleep/circadian behaviour respectively. Disruption of learning, circadian rhythmicity and sleep are likely to have far-reaching detrimental effects on beneficial insects in the field.Kiah TasmanSergio HidalgoBangfu ZhuSean A. RandsJames J. L. HodgeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kiah Tasman Sergio Hidalgo Bangfu Zhu Sean A. Rands James J. L. Hodge Neonicotinoids disrupt memory, circadian behaviour and sleep
description	Abstract Globally, neonicotinoids are the most used insecticides, despite their well-documented sub-lethal effects on beneficial insects. Neonicotinoids are nicotinic acetylcholine receptor agonists. Memory, circadian rhythmicity and sleep are essential for efficient foraging and pollination and require nicotinic acetylcholine receptor signalling. The effect of field-relevant concentrations of the European Union-banned neonicotinoids: imidacloprid, clothianidin, thiamethoxam and thiacloprid were tested on Drosophila memory, circadian rhythms and sleep. Field-relevant concentrations of imidacloprid, clothianidin and thiamethoxam disrupted learning, behavioural rhythmicity and sleep whilst thiacloprid exposure only affected sleep. Exposure to imidacloprid and clothianidin prevented the day/night remodelling and accumulation of pigment dispersing factor (PDF) neuropeptide in the dorsal terminals of clock neurons. Knockdown of the neonicotinoid susceptible Dα1 and Dβ2 nicotinic acetylcholine receptor subunits in the mushroom bodies or clock neurons recapitulated the neonicotinoid like deficits in memory or sleep/circadian behaviour respectively. Disruption of learning, circadian rhythmicity and sleep are likely to have far-reaching detrimental effects on beneficial insects in the field.
format	article
author	Kiah Tasman Sergio Hidalgo Bangfu Zhu Sean A. Rands James J. L. Hodge
author_facet	Kiah Tasman Sergio Hidalgo Bangfu Zhu Sean A. Rands James J. L. Hodge
author_sort	Kiah Tasman
title	Neonicotinoids disrupt memory, circadian behaviour and sleep
title_short	Neonicotinoids disrupt memory, circadian behaviour and sleep
title_full	Neonicotinoids disrupt memory, circadian behaviour and sleep
title_fullStr	Neonicotinoids disrupt memory, circadian behaviour and sleep
title_full_unstemmed	Neonicotinoids disrupt memory, circadian behaviour and sleep
title_sort	neonicotinoids disrupt memory, circadian behaviour and sleep
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/cddb73eff2564c4b9fb52c8cbfc10153
work_keys_str_mv	AT kiahtasman neonicotinoidsdisruptmemorycircadianbehaviourandsleep AT sergiohidalgo neonicotinoidsdisruptmemorycircadianbehaviourandsleep AT bangfuzhu neonicotinoidsdisruptmemorycircadianbehaviourandsleep AT seanarands neonicotinoidsdisruptmemorycircadianbehaviourandsleep AT jamesjlhodge neonicotinoidsdisruptmemorycircadianbehaviourandsleep
_version_	1718396617920348160

Neonicotinoids disrupt memory, circadian behaviour and sleep

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