Relationship Between Gallstone Disease and Cardiometabolic Risk Factors in Elderly People with Non-Alcoholic Fatty Liver Disease
Man-Chen Hung,1 Chuen-Fei Chen,1 Meng-Ting Tsou,2 Hsin-Hui Lin,2 Lee-Ching Hwang,1,2 Ching-Ping Hsu2 1Department of Medicine, Mackay Medical College, New Taipei City, Taiwan; 2Department of Family Medicine, Mackay Memorial Hospital, Taipei, TaiwanCorrespondence: Ching-Ping HsuDepartment of Family Me...
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Dove Medical Press
2020
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oai:doaj.org-article:cddee966733c42d59eab9b71f6259d132021-12-02T11:05:35ZRelationship Between Gallstone Disease and Cardiometabolic Risk Factors in Elderly People with Non-Alcoholic Fatty Liver Disease1178-7007https://doaj.org/article/cddee966733c42d59eab9b71f6259d132020-10-01T00:00:00Zhttps://www.dovepress.com/relationship-between-gallstone-disease-and-cardiometabolic-risk-factor-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Man-Chen Hung,1 Chuen-Fei Chen,1 Meng-Ting Tsou,2 Hsin-Hui Lin,2 Lee-Ching Hwang,1,2 Ching-Ping Hsu2 1Department of Medicine, Mackay Medical College, New Taipei City, Taiwan; 2Department of Family Medicine, Mackay Memorial Hospital, Taipei, TaiwanCorrespondence: Ching-Ping HsuDepartment of Family Medicine, Mackay Memorial Hospital, No. 92, Sec. 2, Zhongshan N. Road, Zhongshan District, Taipei City 104, TaiwanTel +886-2-25433535Fax +886-2-25213847Email drhsuinfo@gmail.comBackground: The prevalence of gallstone disease (GSD) increases with age, and the elderly have a much higher mortality risk and incidence of surgical comorbidities. The aim of this study was to explore the relationship between GSD and cardiometabolic risk factors in elderly people with non-alcoholic fatty liver disease (NAFLD).Methods: In this cross-sectional study, we analyzed the data of elderly people who underwent annual health check-ups at a Northern Taiwan health examination center. These data were collected from physical examination, blood tests, abdominal ultrasonography, and medical histories. We excluded those with hepatitis B or C infections, heavy alcohol consumption, or cholecystectomy.Results: The analysis included 3,037 participants with a mean age of 73.6± 6.0 years. Over 70% were overweight or obese, and the overall prevalence of GSD was 17.7%. In our univariate analysis, GSD was positively correlated with age, body mass index, metabolic syndrome, diabetes mellitus (DM), hypertension (HTN), and various metabolic factors (fasting plasma glucose [FPG], triglyceride, uric acid, and high-density lipoprotein cholesterol [HDL-C] levels). After adjustment for age, gender, and body mass index, metabolic syndrome showed a positive association with GSD (odds ratio [OR] 1.31 [95% confidence interval [CI], 1.05– 1.64]; P=0.020). Specific components of metabolic syndrome that increased the risk for GSD in NAFLD elderly include lower levels of HDL-C (OR 1.35 [95% CI, 1.10– 1.66]; P< 0.001) and elevated FPG (OR 1.36 [95% CI, 1.10– 1.69]; P< 0.001).Conclusion: Our study concluded that GSD is significantly associated with metabolic syndrome in elderly people with NAFLD. Reduced HDL-C and elevated FPG both heighten the risk of developing GSD. Therefore, to lower the risk of GSD in NAFLD patients, their FPG levels and HDL-C levels must be regularly followed-up, and these patients should be educated about the symptoms of GSD if they meet the criteria for metabolic syndrome.Keywords: gallstone disease, cardiometabolic risk factors, metabolic syndromeHung MCChen CFTsou MTLin HHHwang LCHsu CPDove Medical Pressarticlegallstone diseasecardiometabolic risk factorsmetabolic syndromeSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 3579-3585 (2020) |
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gallstone disease cardiometabolic risk factors metabolic syndrome Specialties of internal medicine RC581-951 |
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gallstone disease cardiometabolic risk factors metabolic syndrome Specialties of internal medicine RC581-951 Hung MC Chen CF Tsou MT Lin HH Hwang LC Hsu CP Relationship Between Gallstone Disease and Cardiometabolic Risk Factors in Elderly People with Non-Alcoholic Fatty Liver Disease |
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Man-Chen Hung,1 Chuen-Fei Chen,1 Meng-Ting Tsou,2 Hsin-Hui Lin,2 Lee-Ching Hwang,1,2 Ching-Ping Hsu2 1Department of Medicine, Mackay Medical College, New Taipei City, Taiwan; 2Department of Family Medicine, Mackay Memorial Hospital, Taipei, TaiwanCorrespondence: Ching-Ping HsuDepartment of Family Medicine, Mackay Memorial Hospital, No. 92, Sec. 2, Zhongshan N. Road, Zhongshan District, Taipei City 104, TaiwanTel +886-2-25433535Fax +886-2-25213847Email drhsuinfo@gmail.comBackground: The prevalence of gallstone disease (GSD) increases with age, and the elderly have a much higher mortality risk and incidence of surgical comorbidities. The aim of this study was to explore the relationship between GSD and cardiometabolic risk factors in elderly people with non-alcoholic fatty liver disease (NAFLD).Methods: In this cross-sectional study, we analyzed the data of elderly people who underwent annual health check-ups at a Northern Taiwan health examination center. These data were collected from physical examination, blood tests, abdominal ultrasonography, and medical histories. We excluded those with hepatitis B or C infections, heavy alcohol consumption, or cholecystectomy.Results: The analysis included 3,037 participants with a mean age of 73.6± 6.0 years. Over 70% were overweight or obese, and the overall prevalence of GSD was 17.7%. In our univariate analysis, GSD was positively correlated with age, body mass index, metabolic syndrome, diabetes mellitus (DM), hypertension (HTN), and various metabolic factors (fasting plasma glucose [FPG], triglyceride, uric acid, and high-density lipoprotein cholesterol [HDL-C] levels). After adjustment for age, gender, and body mass index, metabolic syndrome showed a positive association with GSD (odds ratio [OR] 1.31 [95% confidence interval [CI], 1.05– 1.64]; P=0.020). Specific components of metabolic syndrome that increased the risk for GSD in NAFLD elderly include lower levels of HDL-C (OR 1.35 [95% CI, 1.10– 1.66]; P< 0.001) and elevated FPG (OR 1.36 [95% CI, 1.10– 1.69]; P< 0.001).Conclusion: Our study concluded that GSD is significantly associated with metabolic syndrome in elderly people with NAFLD. Reduced HDL-C and elevated FPG both heighten the risk of developing GSD. Therefore, to lower the risk of GSD in NAFLD patients, their FPG levels and HDL-C levels must be regularly followed-up, and these patients should be educated about the symptoms of GSD if they meet the criteria for metabolic syndrome.Keywords: gallstone disease, cardiometabolic risk factors, metabolic syndrome |
format |
article |
author |
Hung MC Chen CF Tsou MT Lin HH Hwang LC Hsu CP |
author_facet |
Hung MC Chen CF Tsou MT Lin HH Hwang LC Hsu CP |
author_sort |
Hung MC |
title |
Relationship Between Gallstone Disease and Cardiometabolic Risk Factors in Elderly People with Non-Alcoholic Fatty Liver Disease |
title_short |
Relationship Between Gallstone Disease and Cardiometabolic Risk Factors in Elderly People with Non-Alcoholic Fatty Liver Disease |
title_full |
Relationship Between Gallstone Disease and Cardiometabolic Risk Factors in Elderly People with Non-Alcoholic Fatty Liver Disease |
title_fullStr |
Relationship Between Gallstone Disease and Cardiometabolic Risk Factors in Elderly People with Non-Alcoholic Fatty Liver Disease |
title_full_unstemmed |
Relationship Between Gallstone Disease and Cardiometabolic Risk Factors in Elderly People with Non-Alcoholic Fatty Liver Disease |
title_sort |
relationship between gallstone disease and cardiometabolic risk factors in elderly people with non-alcoholic fatty liver disease |
publisher |
Dove Medical Press |
publishDate |
2020 |
url |
https://doaj.org/article/cddee966733c42d59eab9b71f6259d13 |
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