Human serum albumin nanoparticles as an efficient noscapine drug delivery system for potential use in breast cancer: preparation and in vitro analysis

Safaa Sebak, Maryam Mirzaei, Meenakshi Malhotra, Arun Kulamarva, Satya PrakashBiomedical Technology and Cell Therapy Research Laboratory, Department of Biomedical Engineering, Faculty of Medicine, McGill University, Montreal, Quebec, CanadaAbstract: Drug delivery systems such as nanoparticles can pr...

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Autores principales:	Safaa Sebak, Maryam Mirzaei, Meenakshi Malhotra, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/cde3b0bdf0f34219898d61f3d26d9c29
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spelling	oai:doaj.org-article:cde3b0bdf0f34219898d61f3d26d9c292021-12-02T07:14:14ZHuman serum albumin nanoparticles as an efficient noscapine drug delivery system for potential use in breast cancer: preparation and in vitro analysis1176-91141178-2013https://doaj.org/article/cde3b0bdf0f34219898d61f3d26d9c292010-09-01T00:00:00Zhttp://www.dovepress.com/human-serum-albumin-nanoparticles-as-an-efficient-noscapine-drug-deliv-a5290https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Safaa Sebak, Maryam Mirzaei, Meenakshi Malhotra, Arun Kulamarva, Satya PrakashBiomedical Technology and Cell Therapy Research Laboratory, Department of Biomedical Engineering, Faculty of Medicine, McGill University, Montreal, Quebec, CanadaAbstract: Drug delivery systems such as nanoparticles can provide enhanced efficacy for &shy;anticancer agents. Noscapine, a widely used cough suppressant for decades has recently been shown to cause significant inhibition and regression of tumor volumes without any detectable &shy;toxicity in cells or tissues. Nanoparticles made of human serum albumin (HSA) represent &shy;promising strategy for targeted drug delivery to tumor cells by enhancing the drug&rsquo;s bioavailability and distribution, and reducing the body&rsquo;s response towards drug resistance. In the &shy;present study, we report for the first time the incorporation and delivery of noscapine-loaded HSA nanoparticles to tumor cells. The nanoparticles were designed and optimized to achieve a particle size in the range of 150&ndash;300 nm with a drug-loading efficiency of 85%&ndash;96%. The nanoparticles were evaluated in vitro for their anticancer activity and efficacy on breast cancer cells.Keywords: HSA, encapsulation, microcapsule, nanomedicine, nanotechnology, tumor volumes Safaa SebakMaryam MirzaeiMeenakshi Malhotraet alDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2010, Iss default, Pp 525-532 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Safaa Sebak Maryam Mirzaei Meenakshi Malhotra et al Human serum albumin nanoparticles as an efficient noscapine drug delivery system for potential use in breast cancer: preparation and in vitro analysis
description	Safaa Sebak, Maryam Mirzaei, Meenakshi Malhotra, Arun Kulamarva, Satya PrakashBiomedical Technology and Cell Therapy Research Laboratory, Department of Biomedical Engineering, Faculty of Medicine, McGill University, Montreal, Quebec, CanadaAbstract: Drug delivery systems such as nanoparticles can provide enhanced efficacy for &shy;anticancer agents. Noscapine, a widely used cough suppressant for decades has recently been shown to cause significant inhibition and regression of tumor volumes without any detectable &shy;toxicity in cells or tissues. Nanoparticles made of human serum albumin (HSA) represent &shy;promising strategy for targeted drug delivery to tumor cells by enhancing the drug&rsquo;s bioavailability and distribution, and reducing the body&rsquo;s response towards drug resistance. In the &shy;present study, we report for the first time the incorporation and delivery of noscapine-loaded HSA nanoparticles to tumor cells. The nanoparticles were designed and optimized to achieve a particle size in the range of 150&ndash;300 nm with a drug-loading efficiency of 85%&ndash;96%. The nanoparticles were evaluated in vitro for their anticancer activity and efficacy on breast cancer cells.Keywords: HSA, encapsulation, microcapsule, nanomedicine, nanotechnology, tumor volumes
format	article
author	Safaa Sebak Maryam Mirzaei Meenakshi Malhotra et al
author_facet	Safaa Sebak Maryam Mirzaei Meenakshi Malhotra et al
author_sort	Safaa Sebak
title	Human serum albumin nanoparticles as an efficient noscapine drug delivery system for potential use in breast cancer: preparation and in vitro analysis
title_short	Human serum albumin nanoparticles as an efficient noscapine drug delivery system for potential use in breast cancer: preparation and in vitro analysis
title_full	Human serum albumin nanoparticles as an efficient noscapine drug delivery system for potential use in breast cancer: preparation and in vitro analysis
title_fullStr	Human serum albumin nanoparticles as an efficient noscapine drug delivery system for potential use in breast cancer: preparation and in vitro analysis
title_full_unstemmed	Human serum albumin nanoparticles as an efficient noscapine drug delivery system for potential use in breast cancer: preparation and in vitro analysis
title_sort	human serum albumin nanoparticles as an efficient noscapine drug delivery system for potential use in breast cancer: preparation and in vitro analysis
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/cde3b0bdf0f34219898d61f3d26d9c29
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Human serum albumin nanoparticles as an efficient noscapine drug delivery system for potential use in breast cancer: preparation and in vitro analysis

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