Filamentous recombinant human Tau activates primary astrocytes via an integrin receptor complex

The mechanisms underlying the transmission of Tau in astrocytes are unclear. Here, the authors show that the entry of filamentous recombinant human Tau into astrocytes via the integrin αV/ β1 complex stimulates integrin signaling, resulting in activation of NFκB and astrocyte conversion towards a ne...

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Autores principales: Peng Wang, Yihong Ye
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/cdec948c96584b6d935eee48df496727
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spelling oai:doaj.org-article:cdec948c96584b6d935eee48df4967272021-12-02T11:56:18ZFilamentous recombinant human Tau activates primary astrocytes via an integrin receptor complex10.1038/s41467-020-20322-w2041-1723https://doaj.org/article/cdec948c96584b6d935eee48df4967272021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20322-whttps://doaj.org/toc/2041-1723The mechanisms underlying the transmission of Tau in astrocytes are unclear. Here, the authors show that the entry of filamentous recombinant human Tau into astrocytes via the integrin αV/ β1 complex stimulates integrin signaling, resulting in activation of NFκB and astrocyte conversion towards a neurotoxic state.Peng WangYihong YeNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Peng Wang
Yihong Ye
Filamentous recombinant human Tau activates primary astrocytes via an integrin receptor complex
description The mechanisms underlying the transmission of Tau in astrocytes are unclear. Here, the authors show that the entry of filamentous recombinant human Tau into astrocytes via the integrin αV/ β1 complex stimulates integrin signaling, resulting in activation of NFκB and astrocyte conversion towards a neurotoxic state.
format article
author Peng Wang
Yihong Ye
author_facet Peng Wang
Yihong Ye
author_sort Peng Wang
title Filamentous recombinant human Tau activates primary astrocytes via an integrin receptor complex
title_short Filamentous recombinant human Tau activates primary astrocytes via an integrin receptor complex
title_full Filamentous recombinant human Tau activates primary astrocytes via an integrin receptor complex
title_fullStr Filamentous recombinant human Tau activates primary astrocytes via an integrin receptor complex
title_full_unstemmed Filamentous recombinant human Tau activates primary astrocytes via an integrin receptor complex
title_sort filamentous recombinant human tau activates primary astrocytes via an integrin receptor complex
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/cdec948c96584b6d935eee48df496727
work_keys_str_mv AT pengwang filamentousrecombinanthumantauactivatesprimaryastrocytesviaanintegrinreceptorcomplex
AT yihongye filamentousrecombinanthumantauactivatesprimaryastrocytesviaanintegrinreceptorcomplex
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