Filamentous recombinant human Tau activates primary astrocytes via an integrin receptor complex
The mechanisms underlying the transmission of Tau in astrocytes are unclear. Here, the authors show that the entry of filamentous recombinant human Tau into astrocytes via the integrin αV/ β1 complex stimulates integrin signaling, resulting in activation of NFκB and astrocyte conversion towards a ne...
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Nature Portfolio
2021
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oai:doaj.org-article:cdec948c96584b6d935eee48df4967272021-12-02T11:56:18ZFilamentous recombinant human Tau activates primary astrocytes via an integrin receptor complex10.1038/s41467-020-20322-w2041-1723https://doaj.org/article/cdec948c96584b6d935eee48df4967272021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20322-whttps://doaj.org/toc/2041-1723The mechanisms underlying the transmission of Tau in astrocytes are unclear. Here, the authors show that the entry of filamentous recombinant human Tau into astrocytes via the integrin αV/ β1 complex stimulates integrin signaling, resulting in activation of NFκB and astrocyte conversion towards a neurotoxic state.Peng WangYihong YeNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021) |
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Science Q Peng Wang Yihong Ye Filamentous recombinant human Tau activates primary astrocytes via an integrin receptor complex |
description |
The mechanisms underlying the transmission of Tau in astrocytes are unclear. Here, the authors show that the entry of filamentous recombinant human Tau into astrocytes via the integrin αV/ β1 complex stimulates integrin signaling, resulting in activation of NFκB and astrocyte conversion towards a neurotoxic state. |
format |
article |
author |
Peng Wang Yihong Ye |
author_facet |
Peng Wang Yihong Ye |
author_sort |
Peng Wang |
title |
Filamentous recombinant human Tau activates primary astrocytes via an integrin receptor complex |
title_short |
Filamentous recombinant human Tau activates primary astrocytes via an integrin receptor complex |
title_full |
Filamentous recombinant human Tau activates primary astrocytes via an integrin receptor complex |
title_fullStr |
Filamentous recombinant human Tau activates primary astrocytes via an integrin receptor complex |
title_full_unstemmed |
Filamentous recombinant human Tau activates primary astrocytes via an integrin receptor complex |
title_sort |
filamentous recombinant human tau activates primary astrocytes via an integrin receptor complex |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/cdec948c96584b6d935eee48df496727 |
work_keys_str_mv |
AT pengwang filamentousrecombinanthumantauactivatesprimaryastrocytesviaanintegrinreceptorcomplex AT yihongye filamentousrecombinanthumantauactivatesprimaryastrocytesviaanintegrinreceptorcomplex |
_version_ |
1718394835956662272 |