Filamentous recombinant human Tau activates primary astrocytes via an integrin receptor complex

The mechanisms underlying the transmission of Tau in astrocytes are unclear. Here, the authors show that the entry of filamentous recombinant human Tau into astrocytes via the integrin αV/ β1 complex stimulates integrin signaling, resulting in activation of NFκB and astrocyte conversion towards a ne...

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Main Authors:	Peng Wang, Yihong Ye
Format:	article
Language:	EN
Published:	Nature Portfolio 2021
Subjects:	Science Q
Online Access:	https://doaj.org/article/cdec948c96584b6d935eee48df496727
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spelling	oai:doaj.org-article:cdec948c96584b6d935eee48df4967272021-12-02T11:56:18ZFilamentous recombinant human Tau activates primary astrocytes via an integrin receptor complex10.1038/s41467-020-20322-w2041-1723https://doaj.org/article/cdec948c96584b6d935eee48df4967272021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20322-whttps://doaj.org/toc/2041-1723The mechanisms underlying the transmission of Tau in astrocytes are unclear. Here, the authors show that the entry of filamentous recombinant human Tau into astrocytes via the integrin αV/ β1 complex stimulates integrin signaling, resulting in activation of NFκB and astrocyte conversion towards a neurotoxic state.Peng WangYihong YeNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Peng Wang Yihong Ye Filamentous recombinant human Tau activates primary astrocytes via an integrin receptor complex
description	The mechanisms underlying the transmission of Tau in astrocytes are unclear. Here, the authors show that the entry of filamentous recombinant human Tau into astrocytes via the integrin αV/ β1 complex stimulates integrin signaling, resulting in activation of NFκB and astrocyte conversion towards a neurotoxic state.
format	article
author	Peng Wang Yihong Ye
author_facet	Peng Wang Yihong Ye
author_sort	Peng Wang
title	Filamentous recombinant human Tau activates primary astrocytes via an integrin receptor complex
title_short	Filamentous recombinant human Tau activates primary astrocytes via an integrin receptor complex
title_full	Filamentous recombinant human Tau activates primary astrocytes via an integrin receptor complex
title_fullStr	Filamentous recombinant human Tau activates primary astrocytes via an integrin receptor complex
title_full_unstemmed	Filamentous recombinant human Tau activates primary astrocytes via an integrin receptor complex
title_sort	filamentous recombinant human tau activates primary astrocytes via an integrin receptor complex
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/cdec948c96584b6d935eee48df496727
work_keys_str_mv	AT pengwang filamentousrecombinanthumantauactivatesprimaryastrocytesviaanintegrinreceptorcomplex AT yihongye filamentousrecombinanthumantauactivatesprimaryastrocytesviaanintegrinreceptorcomplex
_version_	1718394835956662272

Filamentous recombinant human Tau activates primary astrocytes via an integrin receptor complex

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