Lugdunin amplifies innate immune responses in the skin in synergy with host- and microbiota-derived factors

Lugdunin amplifies innate immune responses in the skin in synergy with host- and microbiota-derived factors

Lugdunin is a peptide antibiotic produced by the skin commensal Staphylococcus lugdunensis. Here, the authors show that lugdunin reduces Staphylococcus aureus colonization in human keratinocytes and mouse skin by inducing the expression of human LL-37 and recruitment of monocytes and neutrophils.

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Autores principales: Katharina Bitschar, Birgit Sauer, Jule Focken, Hanna Dehmer, Sonja Moos, Martin Konnerth, Nadine A. Schilling, Stephanie Grond, Hubert Kalbacher, Florian C. Kurschus, Friedrich Götz, Bernhard Krismer, Andreas Peschel, Birgit Schittek
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/cdeeef7531844cd4aa56780138aa628c
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spelling oai:doaj.org-article:cdeeef7531844cd4aa56780138aa628c2021-12-02T15:35:39ZLugdunin amplifies innate immune responses in the skin in synergy with host- and microbiota-derived factors10.1038/s41467-019-10646-72041-1723https://doaj.org/article/cdeeef7531844cd4aa56780138aa628c2019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10646-7https://doaj.org/toc/2041-1723Lugdunin is a peptide antibiotic produced by the skin commensal Staphylococcus lugdunensis. Here, the authors show that lugdunin reduces Staphylococcus aureus colonization in human keratinocytes and mouse skin by inducing the expression of human LL-37 and recruitment of monocytes and neutrophils.Katharina BitscharBirgit SauerJule FockenHanna DehmerSonja MoosMartin KonnerthNadine A. SchillingStephanie GrondHubert KalbacherFlorian C. KurschusFriedrich GötzBernhard KrismerAndreas PeschelBirgit SchittekNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Katharina Bitschar
Birgit Sauer
Jule Focken
Hanna Dehmer
Sonja Moos
Martin Konnerth
Nadine A. Schilling
Stephanie Grond
Hubert Kalbacher
Florian C. Kurschus
Friedrich Götz
Bernhard Krismer
Andreas Peschel
Birgit Schittek
Lugdunin amplifies innate immune responses in the skin in synergy with host- and microbiota-derived factors
description Lugdunin is a peptide antibiotic produced by the skin commensal Staphylococcus lugdunensis. Here, the authors show that lugdunin reduces Staphylococcus aureus colonization in human keratinocytes and mouse skin by inducing the expression of human LL-37 and recruitment of monocytes and neutrophils.
format article
author Katharina Bitschar
Birgit Sauer
Jule Focken
Hanna Dehmer
Sonja Moos
Martin Konnerth
Nadine A. Schilling
Stephanie Grond
Hubert Kalbacher
Florian C. Kurschus
Friedrich Götz
Bernhard Krismer
Andreas Peschel
Birgit Schittek
author_facet Katharina Bitschar
Birgit Sauer
Jule Focken
Hanna Dehmer
Sonja Moos
Martin Konnerth
Nadine A. Schilling
Stephanie Grond
Hubert Kalbacher
Florian C. Kurschus
Friedrich Götz
Bernhard Krismer
Andreas Peschel
Birgit Schittek
author_sort Katharina Bitschar
title Lugdunin amplifies innate immune responses in the skin in synergy with host- and microbiota-derived factors
title_short Lugdunin amplifies innate immune responses in the skin in synergy with host- and microbiota-derived factors
title_full Lugdunin amplifies innate immune responses in the skin in synergy with host- and microbiota-derived factors
title_fullStr Lugdunin amplifies innate immune responses in the skin in synergy with host- and microbiota-derived factors
title_full_unstemmed Lugdunin amplifies innate immune responses in the skin in synergy with host- and microbiota-derived factors
title_sort lugdunin amplifies innate immune responses in the skin in synergy with host- and microbiota-derived factors
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/cdeeef7531844cd4aa56780138aa628c
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