Decreased Circulating Levels of Dickkopf-1 in Patients with Exudative Age-related Macular Degeneration

Abstract Aberrant activation of the Wnt/β-catenin signaling pathway plays a pathogenic role in retinal inflammation and neovascularization. Here, we investigated whether circulating levels of Dickkopf-1 (DKK-1), a specific inhibitor of this pathway, are altered in patients with exudative age-related...

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Autores principales:	Fangfang Qiu, Zhen Liu, Yueping Zhou, Jia He, Songjian Gong, Xue Bai, Yingxia Zeng, Zuguo Liu, Jian-xing Ma
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cdf0975e2edd4c35ab79315c8c731c8f
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spelling	oai:doaj.org-article:cdf0975e2edd4c35ab79315c8c731c8f2021-12-02T15:05:08ZDecreased Circulating Levels of Dickkopf-1 in Patients with Exudative Age-related Macular Degeneration10.1038/s41598-017-01119-22045-2322https://doaj.org/article/cdf0975e2edd4c35ab79315c8c731c8f2017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01119-2https://doaj.org/toc/2045-2322Abstract Aberrant activation of the Wnt/β-catenin signaling pathway plays a pathogenic role in retinal inflammation and neovascularization. Here, we investigated whether circulating levels of Dickkopf-1 (DKK-1), a specific inhibitor of this pathway, are altered in patients with exudative age-related macular degeneration (AMD). Plasma was obtained from 128 patients with exudative AMD, 46 patients with atrophic AMD and 111 healthy controls. DKK-1 levels in plasma were measured using ELISA, and data analyzed with one-way ANOVA, logistic regression analysis and receiver-operating characteristic analysis (ROC). We found that DKK-1 levels were decreased in exudative AMD patients, compared with healthy controls (P < 0.001) and atrophic AMD patients (P < 0.001). The decrease was more prominent in patients with classic choroidal neovascularization (CNV) than those with occult CNV (P < 0.001). The odds ratio (OR) of exudative AMD was 11.71 (95% CI; 5.24–6.13) for lowest versus upper quartile of DKK-1 levels. For discriminating exudative AMD patients, the optimum diagnostic cutoff of DKK-1 was 583.1 pg/mL with the area under curve (AUC) 0.76 (95% CI, 0.70–0.82; P < 0.001), sensitivity 78.1% and specificity 63.1%. These findings suggested that decreased circulating DKK-1 levels are associated with the development and severity of exudative AMD, and have potential to become a biomarker for exudative AMD.Fangfang QiuZhen LiuYueping ZhouJia HeSongjian GongXue BaiYingxia ZengZuguo LiuJian-xing MaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Fangfang Qiu Zhen Liu Yueping Zhou Jia He Songjian Gong Xue Bai Yingxia Zeng Zuguo Liu Jian-xing Ma Decreased Circulating Levels of Dickkopf-1 in Patients with Exudative Age-related Macular Degeneration
description	Abstract Aberrant activation of the Wnt/β-catenin signaling pathway plays a pathogenic role in retinal inflammation and neovascularization. Here, we investigated whether circulating levels of Dickkopf-1 (DKK-1), a specific inhibitor of this pathway, are altered in patients with exudative age-related macular degeneration (AMD). Plasma was obtained from 128 patients with exudative AMD, 46 patients with atrophic AMD and 111 healthy controls. DKK-1 levels in plasma were measured using ELISA, and data analyzed with one-way ANOVA, logistic regression analysis and receiver-operating characteristic analysis (ROC). We found that DKK-1 levels were decreased in exudative AMD patients, compared with healthy controls (P < 0.001) and atrophic AMD patients (P < 0.001). The decrease was more prominent in patients with classic choroidal neovascularization (CNV) than those with occult CNV (P < 0.001). The odds ratio (OR) of exudative AMD was 11.71 (95% CI; 5.24–6.13) for lowest versus upper quartile of DKK-1 levels. For discriminating exudative AMD patients, the optimum diagnostic cutoff of DKK-1 was 583.1 pg/mL with the area under curve (AUC) 0.76 (95% CI, 0.70–0.82; P < 0.001), sensitivity 78.1% and specificity 63.1%. These findings suggested that decreased circulating DKK-1 levels are associated with the development and severity of exudative AMD, and have potential to become a biomarker for exudative AMD.
format	article
author	Fangfang Qiu Zhen Liu Yueping Zhou Jia He Songjian Gong Xue Bai Yingxia Zeng Zuguo Liu Jian-xing Ma
author_facet	Fangfang Qiu Zhen Liu Yueping Zhou Jia He Songjian Gong Xue Bai Yingxia Zeng Zuguo Liu Jian-xing Ma
author_sort	Fangfang Qiu
title	Decreased Circulating Levels of Dickkopf-1 in Patients with Exudative Age-related Macular Degeneration
title_short	Decreased Circulating Levels of Dickkopf-1 in Patients with Exudative Age-related Macular Degeneration
title_full	Decreased Circulating Levels of Dickkopf-1 in Patients with Exudative Age-related Macular Degeneration
title_fullStr	Decreased Circulating Levels of Dickkopf-1 in Patients with Exudative Age-related Macular Degeneration
title_full_unstemmed	Decreased Circulating Levels of Dickkopf-1 in Patients with Exudative Age-related Macular Degeneration
title_sort	decreased circulating levels of dickkopf-1 in patients with exudative age-related macular degeneration
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/cdf0975e2edd4c35ab79315c8c731c8f
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Decreased Circulating Levels of Dickkopf-1 in Patients with Exudative Age-related Macular Degeneration

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