Rate volatility and asymmetric segregation diversify mutation burden in cells with mutator alleles

Dowsett et al use a single-cell resolution approach to analyse the distribution of mutations across several divisions in yeast diploid strains mutated in mismatch repair and polymerase delta proofreading. They find that the underlying mutation rate varies from one division to another, and that new m...

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Autores principales:	Ian T. Dowsett, Jessica L. Sneeden, Branden J. Olson, Jill McKay-Fleisch, Emma McAuley, Scott R. Kennedy, Alan J. Herr
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/cdf0b96bd3134cc3a6076bda3f0f7872
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spelling	oai:doaj.org-article:cdf0b96bd3134cc3a6076bda3f0f78722021-12-02T15:07:32ZRate volatility and asymmetric segregation diversify mutation burden in cells with mutator alleles10.1038/s42003-020-01544-62399-3642https://doaj.org/article/cdf0b96bd3134cc3a6076bda3f0f78722021-01-01T00:00:00Zhttps://doi.org/10.1038/s42003-020-01544-6https://doaj.org/toc/2399-3642Dowsett et al use a single-cell resolution approach to analyse the distribution of mutations across several divisions in yeast diploid strains mutated in mismatch repair and polymerase delta proofreading. They find that the underlying mutation rate varies from one division to another, and that new mutations segregate unequally between sister chromatids at each division, expanding genetic heterogeneity in the population.Ian T. DowsettJessica L. SneedenBranden J. OlsonJill McKay-FleischEmma McAuleyScott R. KennedyAlan J. HerrNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Ian T. Dowsett Jessica L. Sneeden Branden J. Olson Jill McKay-Fleisch Emma McAuley Scott R. Kennedy Alan J. Herr Rate volatility and asymmetric segregation diversify mutation burden in cells with mutator alleles
description	Dowsett et al use a single-cell resolution approach to analyse the distribution of mutations across several divisions in yeast diploid strains mutated in mismatch repair and polymerase delta proofreading. They find that the underlying mutation rate varies from one division to another, and that new mutations segregate unequally between sister chromatids at each division, expanding genetic heterogeneity in the population.
format	article
author	Ian T. Dowsett Jessica L. Sneeden Branden J. Olson Jill McKay-Fleisch Emma McAuley Scott R. Kennedy Alan J. Herr
author_facet	Ian T. Dowsett Jessica L. Sneeden Branden J. Olson Jill McKay-Fleisch Emma McAuley Scott R. Kennedy Alan J. Herr
author_sort	Ian T. Dowsett
title	Rate volatility and asymmetric segregation diversify mutation burden in cells with mutator alleles
title_short	Rate volatility and asymmetric segregation diversify mutation burden in cells with mutator alleles
title_full	Rate volatility and asymmetric segregation diversify mutation burden in cells with mutator alleles
title_fullStr	Rate volatility and asymmetric segregation diversify mutation burden in cells with mutator alleles
title_full_unstemmed	Rate volatility and asymmetric segregation diversify mutation burden in cells with mutator alleles
title_sort	rate volatility and asymmetric segregation diversify mutation burden in cells with mutator alleles
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/cdf0b96bd3134cc3a6076bda3f0f7872
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Rate volatility and asymmetric segregation diversify mutation burden in cells with mutator alleles

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