Phylogenetic analyses of Norwegian Tenacibaculum strains confirm high bacterial diversity and suggest circulation of ubiquitous virulent strains.

Tenacibaculosis is a bacterial ulcerative disease affecting marine fish and represents a major threat to aquaculture worldwide. Its aetiological agents, bacteria belonging to the genus Tenacibaculum, have been present in Norway since at least the late 1980's and lead to regular ulcerative outbr...

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Autores principales:	Erwan Lagadec, Sverre Bang Småge, Christiane Trösse, Are Nylund
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cdf168d5ebc346db9a2d76598c1aaf13
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spelling	oai:doaj.org-article:cdf168d5ebc346db9a2d76598c1aaf132021-12-02T20:13:22ZPhylogenetic analyses of Norwegian Tenacibaculum strains confirm high bacterial diversity and suggest circulation of ubiquitous virulent strains.1932-620310.1371/journal.pone.0259215https://doaj.org/article/cdf168d5ebc346db9a2d76598c1aaf132021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0259215https://doaj.org/toc/1932-6203Tenacibaculosis is a bacterial ulcerative disease affecting marine fish and represents a major threat to aquaculture worldwide. Its aetiological agents, bacteria belonging to the genus Tenacibaculum, have been present in Norway since at least the late 1980's and lead to regular ulcerative outbreaks and high mortalities in production of farmed salmonids. Studies have shown the presence of several Tenacibaculum species in Norway and a lack of clonality in outbreak-related strains, thus preventing the development of an effective vaccine. Hence, a thorough examination of the bacterial diversity in farmed fish presenting ulcers and the geographical distribution of the pathogens should provide important insights needed to strengthen preventive actions. In this study, we investigated the diversity of Tenacibaculum strains isolated in 28 outbreaks that occurred in Norwegian fish farms in the period 2017-2020. We found that 95% of the 66 strains isolated and characterized, using an existing MultiLocus Sequence Typing system, have not previously been identified, confirming the high diversity of this genus of bacteria in Norway. Several of these Tenacibaculum species seem to be present within restricted areas (e.g., Tenacibaculum dicentrarchi in western Norway), but phylogenetic analysis reveals that several of the strains responsible of ulcerative outbreaks were isolated from different localities (e.g., ST- 172 isolated from northern to southern parts of Norway) and/or from different hosts. Understanding their reservoirs and transmission pathways could help to address major challenges in connection with prophylactic measures and development of vaccines.Erwan LagadecSverre Bang SmågeChristiane TrösseAre NylundPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10, p e0259215 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Erwan Lagadec Sverre Bang Småge Christiane Trösse Are Nylund Phylogenetic analyses of Norwegian Tenacibaculum strains confirm high bacterial diversity and suggest circulation of ubiquitous virulent strains.
description	Tenacibaculosis is a bacterial ulcerative disease affecting marine fish and represents a major threat to aquaculture worldwide. Its aetiological agents, bacteria belonging to the genus Tenacibaculum, have been present in Norway since at least the late 1980's and lead to regular ulcerative outbreaks and high mortalities in production of farmed salmonids. Studies have shown the presence of several Tenacibaculum species in Norway and a lack of clonality in outbreak-related strains, thus preventing the development of an effective vaccine. Hence, a thorough examination of the bacterial diversity in farmed fish presenting ulcers and the geographical distribution of the pathogens should provide important insights needed to strengthen preventive actions. In this study, we investigated the diversity of Tenacibaculum strains isolated in 28 outbreaks that occurred in Norwegian fish farms in the period 2017-2020. We found that 95% of the 66 strains isolated and characterized, using an existing MultiLocus Sequence Typing system, have not previously been identified, confirming the high diversity of this genus of bacteria in Norway. Several of these Tenacibaculum species seem to be present within restricted areas (e.g., Tenacibaculum dicentrarchi in western Norway), but phylogenetic analysis reveals that several of the strains responsible of ulcerative outbreaks were isolated from different localities (e.g., ST- 172 isolated from northern to southern parts of Norway) and/or from different hosts. Understanding their reservoirs and transmission pathways could help to address major challenges in connection with prophylactic measures and development of vaccines.
format	article
author	Erwan Lagadec Sverre Bang Småge Christiane Trösse Are Nylund
author_facet	Erwan Lagadec Sverre Bang Småge Christiane Trösse Are Nylund
author_sort	Erwan Lagadec
title	Phylogenetic analyses of Norwegian Tenacibaculum strains confirm high bacterial diversity and suggest circulation of ubiquitous virulent strains.
title_short	Phylogenetic analyses of Norwegian Tenacibaculum strains confirm high bacterial diversity and suggest circulation of ubiquitous virulent strains.
title_full	Phylogenetic analyses of Norwegian Tenacibaculum strains confirm high bacterial diversity and suggest circulation of ubiquitous virulent strains.
title_fullStr	Phylogenetic analyses of Norwegian Tenacibaculum strains confirm high bacterial diversity and suggest circulation of ubiquitous virulent strains.
title_full_unstemmed	Phylogenetic analyses of Norwegian Tenacibaculum strains confirm high bacterial diversity and suggest circulation of ubiquitous virulent strains.
title_sort	phylogenetic analyses of norwegian tenacibaculum strains confirm high bacterial diversity and suggest circulation of ubiquitous virulent strains.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/cdf168d5ebc346db9a2d76598c1aaf13
work_keys_str_mv	AT erwanlagadec phylogeneticanalysesofnorwegiantenacibaculumstrainsconfirmhighbacterialdiversityandsuggestcirculationofubiquitousvirulentstrains AT sverrebangsmage phylogeneticanalysesofnorwegiantenacibaculumstrainsconfirmhighbacterialdiversityandsuggestcirculationofubiquitousvirulentstrains AT christianetrosse phylogeneticanalysesofnorwegiantenacibaculumstrainsconfirmhighbacterialdiversityandsuggestcirculationofubiquitousvirulentstrains AT arenylund phylogeneticanalysesofnorwegiantenacibaculumstrainsconfirmhighbacterialdiversityandsuggestcirculationofubiquitousvirulentstrains
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Phylogenetic analyses of Norwegian Tenacibaculum strains confirm high bacterial diversity and suggest circulation of ubiquitous virulent strains.

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