Naturally-occurring spinosyn A and its derivatives function as argininosuccinate synthase activator and tumor inhibitor

Naturally-occurring spinosyn A and its derivatives function as argininosuccinate synthase activator and tumor inhibitor

Arginine addiction induced by argininosuccinate synthase (ASSN1) deficiency has been exploited to treat ASS1-deficient cancers. Here, the authors show an alternative therapeutic approach where ASS1 activity is increased by the pesticide spinosyn A and is shown to inhibit breast cancer cell prolifera...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Zizheng Zou, Xiyuan Hu, Tiao Luo, Zhengnan Ming, Xiaodan Chen, Li Xia, Wensong Luo, Jijia Li, Na Xu, Ling Chen, Dongsheng Cao, Min Wen, Fanrong Kong, Kunjian Peng, Yuanzhu Xie, Xuan Li, Dayou Ma, Chuanyu Yang, Ceshi Chen, Wenjun Yi, Ousheng Liu, Suyou Liu, Junli Luo, Zhiyong Luo
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/cdf3151bd1624747889b50910c492a74
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:cdf3151bd1624747889b50910c492a74
record_format dspace
spelling oai:doaj.org-article:cdf3151bd1624747889b50910c492a742021-12-02T14:25:16ZNaturally-occurring spinosyn A and its derivatives function as argininosuccinate synthase activator and tumor inhibitor10.1038/s41467-021-22235-82041-1723https://doaj.org/article/cdf3151bd1624747889b50910c492a742021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22235-8https://doaj.org/toc/2041-1723Arginine addiction induced by argininosuccinate synthase (ASSN1) deficiency has been exploited to treat ASS1-deficient cancers. Here, the authors show an alternative therapeutic approach where ASS1 activity is increased by the pesticide spinosyn A and is shown to inhibit breast cancer cell proliferation.Zizheng ZouXiyuan HuTiao LuoZhengnan MingXiaodan ChenLi XiaWensong LuoJijia LiNa XuLing ChenDongsheng CaoMin WenFanrong KongKunjian PengYuanzhu XieXuan LiDayou MaChuanyu YangCeshi ChenWenjun YiOusheng LiuSuyou LiuJunli LuoZhiyong LuoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Zizheng Zou
Xiyuan Hu
Tiao Luo
Zhengnan Ming
Xiaodan Chen
Li Xia
Wensong Luo
Jijia Li
Na Xu
Ling Chen
Dongsheng Cao
Min Wen
Fanrong Kong
Kunjian Peng
Yuanzhu Xie
Xuan Li
Dayou Ma
Chuanyu Yang
Ceshi Chen
Wenjun Yi
Ousheng Liu
Suyou Liu
Junli Luo
Zhiyong Luo
Naturally-occurring spinosyn A and its derivatives function as argininosuccinate synthase activator and tumor inhibitor
description Arginine addiction induced by argininosuccinate synthase (ASSN1) deficiency has been exploited to treat ASS1-deficient cancers. Here, the authors show an alternative therapeutic approach where ASS1 activity is increased by the pesticide spinosyn A and is shown to inhibit breast cancer cell proliferation.
format article
author Zizheng Zou
Xiyuan Hu
Tiao Luo
Zhengnan Ming
Xiaodan Chen
Li Xia
Wensong Luo
Jijia Li
Na Xu
Ling Chen
Dongsheng Cao
Min Wen
Fanrong Kong
Kunjian Peng
Yuanzhu Xie
Xuan Li
Dayou Ma
Chuanyu Yang
Ceshi Chen
Wenjun Yi
Ousheng Liu
Suyou Liu
Junli Luo
Zhiyong Luo
author_facet Zizheng Zou
Xiyuan Hu
Tiao Luo
Zhengnan Ming
Xiaodan Chen
Li Xia
Wensong Luo
Jijia Li
Na Xu
Ling Chen
Dongsheng Cao
Min Wen
Fanrong Kong
Kunjian Peng
Yuanzhu Xie
Xuan Li
Dayou Ma
Chuanyu Yang
Ceshi Chen
Wenjun Yi
Ousheng Liu
Suyou Liu
Junli Luo
Zhiyong Luo
author_sort Zizheng Zou
title Naturally-occurring spinosyn A and its derivatives function as argininosuccinate synthase activator and tumor inhibitor
title_short Naturally-occurring spinosyn A and its derivatives function as argininosuccinate synthase activator and tumor inhibitor
title_full Naturally-occurring spinosyn A and its derivatives function as argininosuccinate synthase activator and tumor inhibitor
title_fullStr Naturally-occurring spinosyn A and its derivatives function as argininosuccinate synthase activator and tumor inhibitor
title_full_unstemmed Naturally-occurring spinosyn A and its derivatives function as argininosuccinate synthase activator and tumor inhibitor
title_sort naturally-occurring spinosyn a and its derivatives function as argininosuccinate synthase activator and tumor inhibitor
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/cdf3151bd1624747889b50910c492a74
work_keys_str_mv AT zizhengzou naturallyoccurringspinosynaanditsderivativesfunctionasargininosuccinatesynthaseactivatorandtumorinhibitor
AT xiyuanhu naturallyoccurringspinosynaanditsderivativesfunctionasargininosuccinatesynthaseactivatorandtumorinhibitor
AT tiaoluo naturallyoccurringspinosynaanditsderivativesfunctionasargininosuccinatesynthaseactivatorandtumorinhibitor
AT zhengnanming naturallyoccurringspinosynaanditsderivativesfunctionasargininosuccinatesynthaseactivatorandtumorinhibitor
AT xiaodanchen naturallyoccurringspinosynaanditsderivativesfunctionasargininosuccinatesynthaseactivatorandtumorinhibitor
AT lixia naturallyoccurringspinosynaanditsderivativesfunctionasargininosuccinatesynthaseactivatorandtumorinhibitor
AT wensongluo naturallyoccurringspinosynaanditsderivativesfunctionasargininosuccinatesynthaseactivatorandtumorinhibitor
AT jijiali naturallyoccurringspinosynaanditsderivativesfunctionasargininosuccinatesynthaseactivatorandtumorinhibitor
AT naxu naturallyoccurringspinosynaanditsderivativesfunctionasargininosuccinatesynthaseactivatorandtumorinhibitor
AT lingchen naturallyoccurringspinosynaanditsderivativesfunctionasargininosuccinatesynthaseactivatorandtumorinhibitor
AT dongshengcao naturallyoccurringspinosynaanditsderivativesfunctionasargininosuccinatesynthaseactivatorandtumorinhibitor
AT minwen naturallyoccurringspinosynaanditsderivativesfunctionasargininosuccinatesynthaseactivatorandtumorinhibitor
AT fanrongkong naturallyoccurringspinosynaanditsderivativesfunctionasargininosuccinatesynthaseactivatorandtumorinhibitor
AT kunjianpeng naturallyoccurringspinosynaanditsderivativesfunctionasargininosuccinatesynthaseactivatorandtumorinhibitor
AT yuanzhuxie naturallyoccurringspinosynaanditsderivativesfunctionasargininosuccinatesynthaseactivatorandtumorinhibitor
AT xuanli naturallyoccurringspinosynaanditsderivativesfunctionasargininosuccinatesynthaseactivatorandtumorinhibitor
AT dayouma naturallyoccurringspinosynaanditsderivativesfunctionasargininosuccinatesynthaseactivatorandtumorinhibitor
AT chuanyuyang naturallyoccurringspinosynaanditsderivativesfunctionasargininosuccinatesynthaseactivatorandtumorinhibitor
AT ceshichen naturallyoccurringspinosynaanditsderivativesfunctionasargininosuccinatesynthaseactivatorandtumorinhibitor
AT wenjunyi naturallyoccurringspinosynaanditsderivativesfunctionasargininosuccinatesynthaseactivatorandtumorinhibitor
AT oushengliu naturallyoccurringspinosynaanditsderivativesfunctionasargininosuccinatesynthaseactivatorandtumorinhibitor
AT suyouliu naturallyoccurringspinosynaanditsderivativesfunctionasargininosuccinatesynthaseactivatorandtumorinhibitor
AT junliluo naturallyoccurringspinosynaanditsderivativesfunctionasargininosuccinatesynthaseactivatorandtumorinhibitor
AT zhiyongluo naturallyoccurringspinosynaanditsderivativesfunctionasargininosuccinatesynthaseactivatorandtumorinhibitor
_version_ 1718391396796203008

Ejemplares similares