The Association Between Hemoglobin HbA1c with Serum Inorganic Phosphate in Children with Type 1 Diabetes

Setila Dalili,1 Shahin Koohmanaee,1 Seyyed Amir Reza Nemati,1 Seyyedeh Azade Hoseini Nouri,1 Afagh Hassanzadeh Rad,1 Wesam Kooti2 1Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran; 2Lung Diseases & Allergy Research Center, Research Institute for Health D...

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Autores principales:	Dalili S, Koohmanaee S, Nemati SAR, Hoseini Nouri SA, Hassanzadeh Rad A, Kooti W
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	phosphate diabetes mellitus child glycated hemoglobin a iran Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/cdf3532a12a4435aa9b1ebdf82de7ded
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spelling	oai:doaj.org-article:cdf3532a12a4435aa9b1ebdf82de7ded2021-12-02T12:07:47ZThe Association Between Hemoglobin HbA1c with Serum Inorganic Phosphate in Children with Type 1 Diabetes1178-7007https://doaj.org/article/cdf3532a12a4435aa9b1ebdf82de7ded2020-09-01T00:00:00Zhttps://www.dovepress.com/the-association-between-hemoglobin-hba1c-with-serum-inorganic-phosphat-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Setila Dalili,1 Shahin Koohmanaee,1 Seyyed Amir Reza Nemati,1 Seyyedeh Azade Hoseini Nouri,1 Afagh Hassanzadeh Rad,1 Wesam Kooti2 1Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran; 2Lung Diseases & Allergy Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, IranCorrespondence: Wesam Kooti; Shahin Koohmanaee Tel +989336583929Email wesamkooti@gmail.com; Koohmana@yahoo.comBackground: Diabetes mellitus is one of the most common chronic metabolic diseases in children and adolescents, which changes the cellular metabolism. Phosphorus is an essential element for metabolism. Early in the progression of diabetes, a paradoxical metabolic imbalance in inorganic phosphate (Pi) occurs that may lead to reduced high energy phosphate and tissue hypoxia. While low and high uncontrolled blood sugars can be easily recognized by clinical symptoms, low and high plasma inorganic phosphate remain unrecognizable. Therefore, we aimed to assess the association between hemoglobin A1c (HbA1c) with serum inorganic phosphate in children with type 1 diabetes.Materials and Methods: This cross-sectional study was conducted on 102 patients selected from a pediatric ward in 17th Shahrivar hospital in Rasht, North of Iran. Clinical data including age, sex, height, weight, BMI, duration of diabetes, the level of HbA1c, and phosphorus were gathered. The level of HbA1c was adjusted by age in the final analysis.Results: The mean age of samples was 9.98± 3.91 years old and 46 participants (45.1%) were male. It was found that HbA1c had a reversed and significant relationship with BMI (r=− 0.215 and P=0.03), but there was no correlation between phosphate, age, height and weight, duration of diabetes mellitus, or rate of insulin consumption with HbA1c (P> 0.05).Conclusion: The finding showed that HbA1c had a reversed relationship with BMI but there was no correlation between phosphate and HbA1c.Keywords: phosphate, diabetes mellitus, child, glycated hemoglobin A, IranDalili SKoohmanaee SNemati SARHoseini Nouri SAHassanzadeh Rad AKooti WDove Medical Pressarticlephosphatediabetes mellituschildglycated hemoglobin airanSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 3405-3409 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	phosphate diabetes mellitus child glycated hemoglobin a iran Specialties of internal medicine RC581-951
spellingShingle	phosphate diabetes mellitus child glycated hemoglobin a iran Specialties of internal medicine RC581-951 Dalili S Koohmanaee S Nemati SAR Hoseini Nouri SA Hassanzadeh Rad A Kooti W The Association Between Hemoglobin HbA1c with Serum Inorganic Phosphate in Children with Type 1 Diabetes
description	Setila Dalili,1 Shahin Koohmanaee,1 Seyyed Amir Reza Nemati,1 Seyyedeh Azade Hoseini Nouri,1 Afagh Hassanzadeh Rad,1 Wesam Kooti2 1Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran; 2Lung Diseases & Allergy Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, IranCorrespondence: Wesam Kooti; Shahin Koohmanaee Tel +989336583929Email wesamkooti@gmail.com; Koohmana@yahoo.comBackground: Diabetes mellitus is one of the most common chronic metabolic diseases in children and adolescents, which changes the cellular metabolism. Phosphorus is an essential element for metabolism. Early in the progression of diabetes, a paradoxical metabolic imbalance in inorganic phosphate (Pi) occurs that may lead to reduced high energy phosphate and tissue hypoxia. While low and high uncontrolled blood sugars can be easily recognized by clinical symptoms, low and high plasma inorganic phosphate remain unrecognizable. Therefore, we aimed to assess the association between hemoglobin A1c (HbA1c) with serum inorganic phosphate in children with type 1 diabetes.Materials and Methods: This cross-sectional study was conducted on 102 patients selected from a pediatric ward in 17th Shahrivar hospital in Rasht, North of Iran. Clinical data including age, sex, height, weight, BMI, duration of diabetes, the level of HbA1c, and phosphorus were gathered. The level of HbA1c was adjusted by age in the final analysis.Results: The mean age of samples was 9.98± 3.91 years old and 46 participants (45.1%) were male. It was found that HbA1c had a reversed and significant relationship with BMI (r=− 0.215 and P=0.03), but there was no correlation between phosphate, age, height and weight, duration of diabetes mellitus, or rate of insulin consumption with HbA1c (P> 0.05).Conclusion: The finding showed that HbA1c had a reversed relationship with BMI but there was no correlation between phosphate and HbA1c.Keywords: phosphate, diabetes mellitus, child, glycated hemoglobin A, Iran
format	article
author	Dalili S Koohmanaee S Nemati SAR Hoseini Nouri SA Hassanzadeh Rad A Kooti W
author_facet	Dalili S Koohmanaee S Nemati SAR Hoseini Nouri SA Hassanzadeh Rad A Kooti W
author_sort	Dalili S
title	The Association Between Hemoglobin HbA1c with Serum Inorganic Phosphate in Children with Type 1 Diabetes
title_short	The Association Between Hemoglobin HbA1c with Serum Inorganic Phosphate in Children with Type 1 Diabetes
title_full	The Association Between Hemoglobin HbA1c with Serum Inorganic Phosphate in Children with Type 1 Diabetes
title_fullStr	The Association Between Hemoglobin HbA1c with Serum Inorganic Phosphate in Children with Type 1 Diabetes
title_full_unstemmed	The Association Between Hemoglobin HbA1c with Serum Inorganic Phosphate in Children with Type 1 Diabetes
title_sort	association between hemoglobin hba1c with serum inorganic phosphate in children with type 1 diabetes
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/cdf3532a12a4435aa9b1ebdf82de7ded
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The Association Between Hemoglobin HbA1c with Serum Inorganic Phosphate in Children with Type 1 Diabetes

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