Evolutionary Trajectory of the Tet(X) Family: Critical Residue Changes towards High-Level Tigecycline Resistance

The newly emerged tigecycline-inactivating enzymes Tet(X3) and Tet(X4), which are associated with high-level tigecycline resistance, demonstrated significantly higher activities in comparison to that of the prototypical Tet(X) enzyme, threatening the clinical efficacy of tigecycline as a last-resor...

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Autores principales:	Chao-Yue Cui, Qian He, Qiu-Lin Jia, Cang Li, Chong Chen, Xiao-Ting Wu, Xiao-Jing Zhang, Zhuo-Yu Lin, Zi-Jian Zheng, Xiao-Ping Liao, Barry N. Kreiswirth, Ya-Hong Liu, Liang Chen, Jian Sun
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2021
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/cdf3b40ab245460288b30206750e79e7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:cdf3b40ab245460288b30206750e79e72021-12-02T17:42:45ZEvolutionary Trajectory of the Tet(X) Family: Critical Residue Changes towards High-Level Tigecycline Resistance2379-507710.1128/mSystems.00050-21https://doaj.org/article/cdf3b40ab245460288b30206750e79e72021-06-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSystems.00050-21https://doaj.org/toc/2379-5077 The newly emerged tigecycline-inactivating enzymes Tet(X3) and Tet(X4), which are associated with high-level tigecycline resistance, demonstrated significantly higher activities in comparison to that of the prototypical Tet(X) enzyme, threatening the clinical efficacy of tigecycline as a last-resort antibiotic to treat multidrug-resistant (MDR) Gram-negative bacterial infections. However, the molecular mechanisms leading to high-level tigecycline resistance remain elusive.Chao-Yue CuiQian HeQiu-Lin JiaCang LiChong ChenXiao-Ting WuXiao-Jing ZhangZhuo-Yu LinZi-Jian ZhengXiao-Ping LiaoBarry N. KreiswirthYa-Hong LiuLiang ChenJian SunAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmSystems, Vol 6, Iss 3 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Chao-Yue Cui Qian He Qiu-Lin Jia Cang Li Chong Chen Xiao-Ting Wu Xiao-Jing Zhang Zhuo-Yu Lin Zi-Jian Zheng Xiao-Ping Liao Barry N. Kreiswirth Ya-Hong Liu Liang Chen Jian Sun Evolutionary Trajectory of the Tet(X) Family: Critical Residue Changes towards High-Level Tigecycline Resistance
description	The newly emerged tigecycline-inactivating enzymes Tet(X3) and Tet(X4), which are associated with high-level tigecycline resistance, demonstrated significantly higher activities in comparison to that of the prototypical Tet(X) enzyme, threatening the clinical efficacy of tigecycline as a last-resort antibiotic to treat multidrug-resistant (MDR) Gram-negative bacterial infections. However, the molecular mechanisms leading to high-level tigecycline resistance remain elusive.
format	article
author	Chao-Yue Cui Qian He Qiu-Lin Jia Cang Li Chong Chen Xiao-Ting Wu Xiao-Jing Zhang Zhuo-Yu Lin Zi-Jian Zheng Xiao-Ping Liao Barry N. Kreiswirth Ya-Hong Liu Liang Chen Jian Sun
author_facet	Chao-Yue Cui Qian He Qiu-Lin Jia Cang Li Chong Chen Xiao-Ting Wu Xiao-Jing Zhang Zhuo-Yu Lin Zi-Jian Zheng Xiao-Ping Liao Barry N. Kreiswirth Ya-Hong Liu Liang Chen Jian Sun
author_sort	Chao-Yue Cui
title	Evolutionary Trajectory of the Tet(X) Family: Critical Residue Changes towards High-Level Tigecycline Resistance
title_short	Evolutionary Trajectory of the Tet(X) Family: Critical Residue Changes towards High-Level Tigecycline Resistance
title_full	Evolutionary Trajectory of the Tet(X) Family: Critical Residue Changes towards High-Level Tigecycline Resistance
title_fullStr	Evolutionary Trajectory of the Tet(X) Family: Critical Residue Changes towards High-Level Tigecycline Resistance
title_full_unstemmed	Evolutionary Trajectory of the Tet(X) Family: Critical Residue Changes towards High-Level Tigecycline Resistance
title_sort	evolutionary trajectory of the tet(x) family: critical residue changes towards high-level tigecycline resistance
publisher	American Society for Microbiology
publishDate	2021
url	https://doaj.org/article/cdf3b40ab245460288b30206750e79e7
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Evolutionary Trajectory of the Tet(X) Family: Critical Residue Changes towards High-Level Tigecycline Resistance

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