Activation of Cph1 causes ß(1,3)-glucan unmasking in Candida albicans and attenuates virulence in mice in a neutrophil-dependent manner.

Masking the immunogenic cell wall epitope ß(1,3)-glucan under an outer layer of mannosylated glycoproteins is an important virulence factor deployed by Candida albicans during infection. Consequently, increased ß(1,3)-glucan exposure (unmasking) reveals C. albicans to the host's immune system a...

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Autores principales: Andrew S Wagner, Trevor J Hancock, Stephen W Lumsdaine, Sarah J Kauffman, Mikayla M Mangrum, Elise K Phillips, Timothy E Sparer, Todd B Reynolds
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
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Acceso en línea:https://doaj.org/article/cdfab09a60b748168be22f81e6fb3981
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