Telomere length shows no association with BRCA1 and BRCA2 mutation status.

This study aimed to determine whether telomere length (TL) is a marker of cancer risk or genetic status amongst two cohorts of BRCA1 and BRCA2 mutation carriers and controls. The first group was a prospective set of 665 male BRCA1/2 mutation carriers and controls (mean age 53 years), all healthy at...

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Autores principales:	Emma Killick, Malgorzata Tymrakiewicz, Clara Cieza-Borrella, Paula Smith, Deborah J Thompson, Karen A Pooley, Doug F Easton, Elizabeth Bancroft, Elizabeth Page, Daniel Leongamornlert, IMPACT collaborators, Zsofia Kote-Jarai, Rosalind A Eeles
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cdfabafadb5b476489a69b8ed1a6df47
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spelling	oai:doaj.org-article:cdfabafadb5b476489a69b8ed1a6df472021-11-18T08:35:10ZTelomere length shows no association with BRCA1 and BRCA2 mutation status.1932-620310.1371/journal.pone.0086659https://doaj.org/article/cdfabafadb5b476489a69b8ed1a6df472014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24489760/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203This study aimed to determine whether telomere length (TL) is a marker of cancer risk or genetic status amongst two cohorts of BRCA1 and BRCA2 mutation carriers and controls. The first group was a prospective set of 665 male BRCA1/2 mutation carriers and controls (mean age 53 years), all healthy at time of enrollment and blood donation, 21 of whom have developed prostate cancer whilst on study. The second group consisted of 283 female BRCA1/2 mutation carriers and controls (mean age 48 years), half of whom had been diagnosed with breast cancer prior to enrollment. TL was quantified by qPCR from DNA extracted from peripheral blood lymphocytes. Weighted and unweighted Cox regressions and linear regression analyses were used to assess whether TL was associated with BRCA1/2 mutation status or cancer risk. We found no evidence for association between developing cancer or being a BRCA1 or BRCA2 mutation carrier and telomere length. It is the first study investigating TL in a cohort of genetically predisposed males and although TL and BRCA status was previously studied in females our results don't support the previous finding of association between hereditary breast cancer and shorter TL.Emma KillickMalgorzata TymrakiewiczClara Cieza-BorrellaPaula SmithDeborah J ThompsonKaren A PooleyDoug F EastonElizabeth BancroftElizabeth PageDaniel LeongamornlertIMPACT collaboratorsZsofia Kote-JaraiRosalind A EelesPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 1, p e86659 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Emma Killick Malgorzata Tymrakiewicz Clara Cieza-Borrella Paula Smith Deborah J Thompson Karen A Pooley Doug F Easton Elizabeth Bancroft Elizabeth Page Daniel Leongamornlert IMPACT collaborators Zsofia Kote-Jarai Rosalind A Eeles Telomere length shows no association with BRCA1 and BRCA2 mutation status.
description	This study aimed to determine whether telomere length (TL) is a marker of cancer risk or genetic status amongst two cohorts of BRCA1 and BRCA2 mutation carriers and controls. The first group was a prospective set of 665 male BRCA1/2 mutation carriers and controls (mean age 53 years), all healthy at time of enrollment and blood donation, 21 of whom have developed prostate cancer whilst on study. The second group consisted of 283 female BRCA1/2 mutation carriers and controls (mean age 48 years), half of whom had been diagnosed with breast cancer prior to enrollment. TL was quantified by qPCR from DNA extracted from peripheral blood lymphocytes. Weighted and unweighted Cox regressions and linear regression analyses were used to assess whether TL was associated with BRCA1/2 mutation status or cancer risk. We found no evidence for association between developing cancer or being a BRCA1 or BRCA2 mutation carrier and telomere length. It is the first study investigating TL in a cohort of genetically predisposed males and although TL and BRCA status was previously studied in females our results don't support the previous finding of association between hereditary breast cancer and shorter TL.
format	article
author	Emma Killick Malgorzata Tymrakiewicz Clara Cieza-Borrella Paula Smith Deborah J Thompson Karen A Pooley Doug F Easton Elizabeth Bancroft Elizabeth Page Daniel Leongamornlert IMPACT collaborators Zsofia Kote-Jarai Rosalind A Eeles
author_facet	Emma Killick Malgorzata Tymrakiewicz Clara Cieza-Borrella Paula Smith Deborah J Thompson Karen A Pooley Doug F Easton Elizabeth Bancroft Elizabeth Page Daniel Leongamornlert IMPACT collaborators Zsofia Kote-Jarai Rosalind A Eeles
author_sort	Emma Killick
title	Telomere length shows no association with BRCA1 and BRCA2 mutation status.
title_short	Telomere length shows no association with BRCA1 and BRCA2 mutation status.
title_full	Telomere length shows no association with BRCA1 and BRCA2 mutation status.
title_fullStr	Telomere length shows no association with BRCA1 and BRCA2 mutation status.
title_full_unstemmed	Telomere length shows no association with BRCA1 and BRCA2 mutation status.
title_sort	telomere length shows no association with brca1 and brca2 mutation status.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/cdfabafadb5b476489a69b8ed1a6df47
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Telomere length shows no association with BRCA1 and BRCA2 mutation status.

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