Structural insight into small molecule action on Frizzleds

Structural insight into small molecule action on Frizzleds

WNT-Frizzled (FZD) signaling plays a critical role in embryonic development, tissue homeostasis and human disease but no small molecule drugs targeting FZD with distinct efficacy have emerged so far. Here, authors identify the Smoothened agonist SAG1.3 as a partial agonist for FZD6 with limited subt...

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Autores principales: Paweł Kozielewicz, Ainoleena Turku, Carl-Fredrik Bowin, Julian Petersen, Jana Valnohova, Maria Consuelo Alonso Cañizal, Yuki Ono, Asuka Inoue, Carsten Hoffmann, Gunnar Schulte
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/cdfb04c677084c808ef1126575dae7a6
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spelling oai:doaj.org-article:cdfb04c677084c808ef1126575dae7a62021-12-02T16:49:28ZStructural insight into small molecule action on Frizzleds10.1038/s41467-019-14149-32041-1723https://doaj.org/article/cdfb04c677084c808ef1126575dae7a62020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14149-3https://doaj.org/toc/2041-1723WNT-Frizzled (FZD) signaling plays a critical role in embryonic development, tissue homeostasis and human disease but no small molecule drugs targeting FZD with distinct efficacy have emerged so far. Here, authors identify the Smoothened agonist SAG1.3 as a partial agonist for FZD6 with limited subtype selectivity.Paweł KozielewiczAinoleena TurkuCarl-Fredrik BowinJulian PetersenJana ValnohovaMaria Consuelo Alonso CañizalYuki OnoAsuka InoueCarsten HoffmannGunnar SchulteNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Paweł Kozielewicz
Ainoleena Turku
Carl-Fredrik Bowin
Julian Petersen
Jana Valnohova
Maria Consuelo Alonso Cañizal
Yuki Ono
Asuka Inoue
Carsten Hoffmann
Gunnar Schulte
Structural insight into small molecule action on Frizzleds
description WNT-Frizzled (FZD) signaling plays a critical role in embryonic development, tissue homeostasis and human disease but no small molecule drugs targeting FZD with distinct efficacy have emerged so far. Here, authors identify the Smoothened agonist SAG1.3 as a partial agonist for FZD6 with limited subtype selectivity.
format article
author Paweł Kozielewicz
Ainoleena Turku
Carl-Fredrik Bowin
Julian Petersen
Jana Valnohova
Maria Consuelo Alonso Cañizal
Yuki Ono
Asuka Inoue
Carsten Hoffmann
Gunnar Schulte
author_facet Paweł Kozielewicz
Ainoleena Turku
Carl-Fredrik Bowin
Julian Petersen
Jana Valnohova
Maria Consuelo Alonso Cañizal
Yuki Ono
Asuka Inoue
Carsten Hoffmann
Gunnar Schulte
author_sort Paweł Kozielewicz
title Structural insight into small molecule action on Frizzleds
title_short Structural insight into small molecule action on Frizzleds
title_full Structural insight into small molecule action on Frizzleds
title_fullStr Structural insight into small molecule action on Frizzleds
title_full_unstemmed Structural insight into small molecule action on Frizzleds
title_sort structural insight into small molecule action on frizzleds
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/cdfb04c677084c808ef1126575dae7a6
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AT carlfredrikbowin structuralinsightintosmallmoleculeactiononfrizzleds
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